Noxafil (Posaconazole Oral Suspension) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Noxafil

Yeast Infection »

What is yeast?

Yeast is a fungus scientifically referred to as Candida. The specific type of fungus most commonly responsible for vaginitis is Candida albicans. Yeast is commonly present on normal human skin and in areas of moisture, such as the mouth and vagina. In fact, it is estimated that between 20%-50% of healthy women normally carry yeast in the vaginal area.

What is vaginitis?

Vaginitis is inflammation of the vagina. Vaginitis is very common and is reported by as many as 75% of women at some point in their lives. Vaginitis can be caused by a number of infections, including bacteria (such as Gardnerella and gonorrhea), protozoans (such as trichomonas), and yeast (Candida). Vaginal yeast infection, which is the most common form of vaginitis, is often referred to as vaginal Candidiasis.

What is vulvitis?

Vulvitis is inflammation of the external ...

Read the Yeast Infection article »

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Noxafil

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NOXAFIL®
(posaconazole) Oral Suspension 40 mg/mL

DRUG DESCRIPTION

NOXAFIL (posaconazole oral suspension) is a triazole antifungal agent available as a suspension for oral administration.

Posaconazole is designated chemically as 4-[4-[4-[4-[[ (3R,5R)-5- (2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-[ (1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one with an empirical formula of C₃₇H₄₂F₂N₈O₄ and a molecular weight of 700.8. The chemical structure is:

NOXAFIL® (Posaconazole) Structural Formula Illustration

Posaconazole is a white powder and is insoluble in water.

NOXAFIL (posaconazole oral suspension) Oral Suspension is a white, cherry-flavored immediate-release suspension containing 40 mg of posaconazole per mL and the following inactive ingredients: polysorbate 80, simethicone, sodium benzoate, sodium citrate dihydrate, citric acid monohydrate, glycerin, xanthan gum, liquid glucose, titanium dioxide, artificial cherry flavor, and purified water.

What are the possible side effects of posaconazole (Noxafil)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

pale skin, easy bruising or bleeding, unusual weakness;
fever, chills, cough, body aches, flu symptoms;
slow, fast, or pounding heartbeats;
feeling light-headed, fainting;
numbness or tingly feeling around your mouth, fast or slow heart rate, muscle...

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What are the precautions when taking posaconazole oral suspension (Noxafil)?

Before taking posaconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals (e.g., ketoconazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, heart disease (e.g., irregular heartbeat).

Posaconazole may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that require immediate medical attention. The risk of QT...

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Last reviewed on RxList: 10/12/2010
This monograph has been modified to include the generic and brand name in many instances.