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This drug should not be used with the following medications because very serious interactions may occur: ergot alkaloids (e.g., ergotamine, dihydroergotamine), sirolimus.

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting posaconazole.

Many drugs besides posaconazole may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), cisapride, halofantrine, ranolazine, disopyramide, ziprasidone, thioridazine, among others. Therefore, before using posaconazole, report all medications you are currently using to your doctor or pharmacist.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: certain drugs for diabetes (e.g., sulfonylureas such as glipizide, glyburide), esomeprazole, metoclopramide, drugs affecting liver enzymes that remove posaconazole from your body (such as cimetidine, efavirenz, rifamycins including rifabutin, certain anti-seizure medications including phenytoin).

This drug can slow down the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include certain immunosuppressants (e.g., tacrolimus, cyclosporine), vinca alkaloids (e.g., vinblastine, vincristine), certain benzodiazepines (e.g., midazolam, triazolam, alprazolam), certain calcium channel blockers (e.g., nifedipine), certain "statin" drugs (e.g., simvastatin, lovastatin), HIV protease inhibitors (e.g., atazanavir, ritonavir), tolterodine, eplerenone, digoxin.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later to prevent another infection unless told to do so by your doctor. A different medication may be necessary in that case.

Laboratory and/or medical tests (e.g., liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not freeze. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised May 2010 Copyright(c) 2010 First DataBank, Inc.