DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: certain drugs for diabetes (e.g., sulfonylureas such as glipizide, glyburide), ergot alkaloids (e.g., ergotamine, dihydroergotamine), esomeprazole, metoclopramide, sirolimus, drugs affecting liver enzymes that remove posaconazole from your body (such as cimetidine, efavirenz, rifamycins including rifabutin, certain anti-seizure medications including phenytoin).

Many drugs besides posaconazole may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), cisapride, halofantrine, ranolazine, disopyramide, ziprasidone, thioridazine, among others. Therefore, before using posaconazole, report all medications you are currently using to your doctor or pharmacist.

This drug can slow down the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include certain immunosuppressants (e.g., tacrolimus, cyclosporine), vinca alkaloids (e.g., vinblastine, vincristine), certain benzodiazepines (e.g., midazolam, triazolam, alprazolam), certain calcium channel blockers (e.g., nifedipine), certain "statin" drugs (e.g., simvastatin, lovastatin), HIV protease inhibitors (e.g., atazanavir, ritonavir), tolterodine, eplerenone, digoxin.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later to prevent another infection unless told to do so by your doctor. A different medication may be necessary in that case.

Laboratory and/or medical tests (e.g., liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not freeze. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised June 2011. Copyright(c) 2011 First Databank, Inc.