In this Article

• What is posaconazole (Noxafil)?
• What are the possible side effects of posaconazole (Noxafil)?
• What is the most important information I should know about posaconazole (Noxafil)?
• What should I discuss with my healthcare provider before using posaconazole (Noxafil)?
• How should I take posaconazole (Noxafil)?
• What happens if I miss a dose (Noxafil)?
• What happens if I overdose (Noxafil)?
• What should I avoid while taking posaconazole (Noxafil)?
• What other drugs will affect posaconazole (Noxafil)?
• Where can I get more information?

What should I discuss with my healthcare provider before using posaconazole (Noxafil)?

You should not use this medication if you are allergic to posaconazole, or if you are using any of the following drugs:

• halofantrine (Halfan);
• pimozide (Orap);
• quinidine (Quin-G);
• simvastatin (Zocor, Simcor, Vytorin);
• sirolimus (Rapamune) or tacrolimus (Prograf); or
• ergot medicine such as ergotamine (Ergomar), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

To make sure you can safely take posaconazole, tell your doctor if you have any of these other conditions:

• a personal or family history of "Long QT syndrome";
• a history of allergy to antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
• liver disease; or
• a heart rhythm disorder.

FDA pregnancy category C. It is not known whether posaconazole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether posaconazole passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medication to a child younger than 13 years old.

How should I take posaconazole (Noxafil)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Posaconazole works best if you take it within 20 minutes after a full meal or a nutritional supplement (such as Ensure).

Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Call your doctor if you have ongoing vomiting or diarrhea. Posaconazole may not work as well while during this time.

To be sure this medication is not causing harmful effects, your blood may need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.

Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Posaconazole will not treat a viral infection such as the common cold or flu.

Store at room temperature away from moisture and heat.