NSAIDs (Nonsteroidal Antiinflammatory Drugs) (cont.)
Annette (Gbemudu) Ogbru, PharmD, MBA
Dr. Gbemudu received her B.S. in Biochemistry from Nova Southeastern University, her PharmD degree from University of Maryland, and MBA degree from University of Baltimore. She completed a one year post-doctoral fellowship with Rutgers University and Bristol Myers Squibb.
In this Article
- What are NSAIDs and how do they work?
- For what conditions are NSAIDs used?
- Are there any differences between NSAIDs?
- What are the side effects of NSAIDs?
- With which drugs do NSAIDs interact?
- What are some examples of approved NSAIDS in the United States?
With which drugs do NSAIDs interact?
NSAIDs may reduce the benefit of drugs used for treating hypertension because NSAIDs may increase blood pressure. NSAIDs decrease the elimination of lithium (Eskalith) and methotrexate (Rheumatrex) potentially leading to their toxicity, and reduce the action of diuretics ("water pills") by reducing blood flow to the kidneys. NSAIDs increase bleeding by decreasing the activity of blood platelets and therefore formation of blood clots. When used with other drugs that also increase bleeding, for example, warfarin (Coumadin), the likelihood of bleeding complications is increased. Prolonged use of NSAIDs with drugs that increase bleeding should be avoided.
What are some examples of approved NSAIDS in the United States?
The following list contains only NSAIDs that are commonly used:
- salsalate (Amigesic)
- celecoxib (Celebrex),
- diclofenac (Voltaren),
- etodolac (Lodine),
- ibuprofen (Motrin),
- indomethacin (Indocin),
- ketoprofen (Orudis),
- ketorolac (Toradol),
- nabumetone (Relafen),
- naproxen (Aleve, Naprosyn),
- oxaprozin (Daypro),
- piroxicam (Feldene),
- sulindac (Clinoril), and
- tolmetin (Tolectin).
REFERENCE: FDA Prescribing Information.
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