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Nubain Patient Information including How Should I Take

What should I discuss with my healthcare provider before I receive nalbuphine (Nubain)?

You should not receive this medication if you are allergic to nalbuphine.

Nalbuphine may cause unpleasant side effects if you are already taking other narcotic pain medicines. Before you receive nalbuphine, tell your doctor about all other pain medicines you have recently used.

Nalbuphine may be habit-forming and should be used only by the person it was prescribed for. Nalbuphine should never be shared with another person, especially someone who has a history of drug abuse or addiction.

Before receiving nalbuphine, tell your doctor if you are allergic to any drugs, or if you have:

  • asthma, COPD (chronic obstructive pulmonary disease), or other breathing disorder;
  • liver or kidney disease;
  • a history of head injury or brain tumor;
  • gallbladder disease;
  • mental illness; or
  • a history of drug or alcohol addiction.

FDA pregnancy category B. Nalbuphine is not expected to be harmful to an unborn baby. However, do not receive this medication without telling your doctor if you are pregnant.

Nalbuphine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is nalbuphine given (Nubain)?

This medication is given as an injection into a muscle or under your skin, or through a needle placed into a vein. You will receive this injection in a clinic or hospital setting.

Nalbuphine is usually given every 3 to 6 hours.

Tell your doctor if the medicine seems to stop working as well in relieving your pain.

You should not stop using nalbuphine suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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