Nucynta (Tapentadol Immediate-Release Oral Tablets) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

Nucynta

Lower Back Pain »

Low back pain facts

Functions of the low back, or lumbar area, include structural support, movement, and protection of certain body tissues.
Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae, ligaments around the spine and discs, spinal cord and nerves, muscles of the low back, internal organs of the pelvis and abdomen, and the skin covering the lumbar area.
Treatment of low back pain is optimally directed toward a diagnosed or suspected specific cause. For acute lumbar strain, use of a home remedy initially can be beneficial.

What is the anatomy of the low back?

The first step to understanding low back pain is appreciating the normal design (anatomy) of the tissues of this area of the body. Important structures of the low back that can be related to symptoms in this region include the bony lumbar spine (vertebrae, singular = vert...

Read the Lower Back Pain article »

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NUCYNTA®
(tapentadol) Immediate-Release Oral Tablets

DRUG DESCRIPTION

NUCYNTA® (tapentadol) Tablets are immediate-release film-coated tablets for oral administration. The chemical name is 3-[(1R,2R)-3-(dimethylamino)-l-ethyl-2-methylpropyl]phenol monohydrochloride. The structural formula is:

NUCYNTA®
(tapentadol) Structural Formula Illustration

The molecular weight of tapentadol HC1 is 257.80, and the molecular formula is C₁₄H₂₃NO·HCl. The n-octanol:water partition coefficient log P value is 2.87. The pKa values are 9.34 and 10.45. In addition to the active ingredient tapentadol HC1, tablets also contain the following inactive ingredients: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, povidone, magnesium stearate, and Opadry® II, a proprietary film-coating mixture containing polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and aluminum lake coloring.

What are the possible side effects of tapentadol (Nucynta)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

weak or shallow breathing, weak pulse, slow heartbeat;
seizure (convulsions);
severe drowsiness or dizziness;
confusion, problems with speech or balance; or
agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting,...

Read All Potential Side Effects and See Pictures of Nucynta »

Last reviewed on RxList: 12/9/2010
This monograph has been modified to include the generic and brand name in many instances.