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(tapentadol) Oral Solution
NUCYNTA® (tapentadol) is a mu-opioid receptor agonist, supplied in a liquid solution for oral adminsitration. The chemical name is 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2methylpropyl]phenol monohydrochloride. The structural formula is:
The molecular weight of tapentadol HCl is 257.80, and the molecular formula is C14H23NO·HCl. The n-octanol:water partition coefficient log P value is 2.87. The pKa values are 9.34 and 10.45.
NUCYNTA® (tapentadol) oral solution is supplied as a clear, colorless solution and contains 20 mg/mL of tapentadol (corresponding to 23 mg/mL of tapentadol hydrochloride) and the following inactive ingredients: citric acid monohydrate, purified water, raspberry flavor, sodium hydroxide, and sucralose.
What are the possible side effects of tapentadol (Nucynta, Nucynta ER)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- weak or shallow breathing, weak pulse, slow heartbeat;
- seizure (convulsions);
- severe drowsiness or dizziness;
- confusion, problems with speech or balance; or
- agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination,...
Last reviewed on RxList: 12/4/2014
This monograph has been modified to include the generic and brand name in many instances.
Additional Nucynta Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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