Nuedexta Capsules (Dextromethorphan Hydrobromide and Quinidine Sulfate Capsules) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

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Nuedexta Capsules

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NUEDEXTA
(dextromethorphan hydrobromide and quinidine sulfate) Capsules

DRUG DESCRIPTION

NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) is an oral formulation of dextromethorphan hydrobromide USP and quinidine sulfate USP in a fixed dose combination.

Dextromethorphan hydrobromide is the pharmacologically active ingredient of NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) that acts on the central nervous system (CNS). The chemical name is dextromethorphan hydrobromide: morphinan, 3-methoxy-17-methyl-, (9α, 13α, 14α), hydrobromide monohydrate. Dextromethorphan hydrobromide has the empirical formula C₁₈H₂₅NO•HBr•H₂O with a molecular weight of 370.33. The structural formula is:

Dextromethorphan hydrobromide Structural Formula Illustration

Quinidine sulfate is a specific inhibitor of CYP2D6-dependent oxidative metabolism used in NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) to increase the systemic bioavailability of dextromethorphan. The chemical name is quinidine sulfate: cinchonan-9-01,6'-methoxy-, (9S) sulfate (2:1), (salt), dihydrate. Quinidine sulfate dihydrate has the empirical formula of (C₂₀H₂₄N₂O₂)₂•H₂SO₄•2H₂O with a molecular weight of 782.96. The structural formula is:

Quinidine sulfate Structural Formula Illustration

The combination product, NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) , is a white to off-white powder. NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) is available for oral use as NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) which contains 20 mg dextromethorphan hydrobromide and 10 mg quinidine sulfate. The active ingredients are dextromethorphan hydrobromide monohydrate USP and quinidine sulfate dihydrate USP. Inactive ingredients in the capsule are croscarmellose sodium NF, microcrystalline cellulose NF, colloidal silicon dioxide NF, lactose monohydrate NF, and magnesium stearate NF.

What are the precautions when taking dextromethorphan hydrobromide and quinidine sulfate capsules (Nuedexta Capsules)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to dextromethorphan, quinidine, quinine, or mefloquine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood/bone marrow disorder (such as low platelets/white blood cells/red blood cells), kidney disease, liver disease, lupus-like syndrome, myasthenia gravis.

Quinidine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe...

Read All Potential Precautions of Nuedexta Capsules »

Last reviewed on RxList: 12/10/2010
This monograph has been modified to include the generic and brand name in many instances.