Physicians are advised to discuss the following topics with patients for whom they prescribe NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) :

Hypersensitivity

Patients should be advised a hypersensitivity reaction to NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) could occur. Patients should be instructed to seek medical attention immediately if they experience symptoms indicative of hypersensitivity after taking NUEDEXTA [see CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS].

Cardiac effects

Patients should be advised to consult their healthcare provider immediately if they feel faint or lose consciousness. Patients should be counseled to inform their healthcare provider if they have any personal or family history of QTc prolongation [see CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, DRUG INTERACTIONS].

Dizziness

Patients should be advised that NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) may cause dizziness. Precautions to reduce the risk of falls should be taken, particularly for patients with motor impairment affecting gait or a history of falls [see WARNINGS AND PRECAUTIONS, ADVERSE REACTIONS].

Drug Interactions

Inform patients that NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) increases the risk of adverse drug interactions, Instruct patients to inform their healthcare provider about all the medications that they are taking before taking NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) . Before taking any new medications, patients should tell their healthcare provider that they are taking NUEDEXTA [see DRUG INTERACTIONS].

Benefits and Risks

Summarize for patients the risks of treatment with NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) . Advise patients to tell their healthcare provider if they have side effects that bother them or do not go away.

Dosing Instructions

Instruct patients to take NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) exactly as prescribed. Instruct patients not to take more than 2 capsules in a 24-hour period and to make sure that there is an approximate 12-hour interval between doses, and not to take a double dose after they miss a dose.

General

Patients should not share or give NUEDEXTA (dextromethorphan hydrobromide and quinidine sulfate capsules) to others, even if they have the same symptoms, because it may harm them.

Advise patients to contact their healthcare provider if their PBA symptoms persist or worsen. Advise patients to keep this and all medications out of reach of children and pets.

Last reviewed on RxList: 12/10/2010
This monograph has been modified to include the generic and brand name in many instances.