Nystatin and Triamcinolone Acetonide (nystatin and triamcinolone acetonide cream, ointment) Cream and Ointment for dermatologic use contain the antifungal agent nystatin and the synthetic corticosteroid triamcinolone acetonide.

Nystatin is a polyene antimycotic obtained from Streptomyces noursei. It is a yellow to light tan powder with a cereal-like odor, very slightly soluble in water, and slightly to sparingly soluble in alcohol. Structural formula:

C₄₇H₇₅NO₁₇..............MW = 926.13

Triamcinolone acetonide is designated chemically as 9-fluoro-11β, 16, 17, 21-tetrahydroxypregna-1, 4-diene-3, 20-dione cyclic 16, 17-acetal with acetone. The white to cream crystalline powder has a slight odor, is practically insoluble in water, and very soluble in alcohol. Structural formula:

C₂₄H₃₁FO₆...................MW = 434.50

Nystatin and Triamcinolone Acetonide (nystatin and triamcinolone acetonide cream, ointment) Cream is a soft, smooth cream having a light yellow to buff color. Each gram provides 100,000 USP Nystatin units and 1 mg Triamcinolone Acetonide in an aqueous perfumed vanishing cream base with polysorbate-60, aluminum hydroxide, titanium dioxide, glyceryl monostearate, polyethylene glycol monostearate, simethicone emulsion, sorbic acid, propylene glycol, white petrolatum, polyoxyethylene fatty alcohol ether, methylparaben, propylparaben and sorbitol.

Each gram of Nystatin and Triamcinolone Acetonide (nystatin and triamcinolone acetonide cream, ointment) Ointment provides 100,000 USP Nystatin units and 1 mg Triamcinolone Acetonide in an ointment base of mineral oil and white petrolatum.

Last reviewed on RxList: 8/11/2008
This monograph has been modified to include the generic and brand name in many instances.