"SAN DIEGO, California â€” A novel liposomal formulation of cytarabine and daunorubicin, known as CPX-351 (Vyxeos, Jazz Pharmaceuticals), has again been shown to be superior to a standard version of this combination, the 7+3 regimen of cytara"...
High doses of fludarabine phosphate [See INDICATIONS AND USAGE and WARNINGS AND PRECAUTIONS] have been associated with an irreversible central nervous system toxicity characterized by delayed blindness, coma and death. High doses are also associated with severe thrombocytopenia and neutropenia due to bone marrow suppression. There is no known specific antidote for fludarabine phosphate overdosage. Treatment consists of drug discontinuation and supportive therapy. In Study 2, two patients ingested an overdose of 20% to 33% of Oforta™ (fludarabine phosphate tablets) . No serious side effects were reported.
NoneThis monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 8/5/2009
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