November 27, 2015
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"The U.S. Food and Drug Administration today approved a new use of Gleevec (imatinib) to treat children newly diagnosed with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL).

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High doses of fludarabine phosphate [See INDICATIONS AND USAGE and WARNINGS AND PRECAUTIONS] have been associated with an irreversible central nervous system toxicity characterized by delayed blindness, coma and death. High doses are also associated with severe thrombocytopenia and neutropenia due to bone marrow suppression. There is no known specific antidote for fludarabine phosphate overdosage. Treatment consists of drug discontinuation and supportive therapy. In Study 2, two patients ingested an overdose of 20% to 33% of Oforta™ (fludarabine phosphate tablets) . No serious side effects were reported.



This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 8/5/2009


Oforta - User Reviews

Oforta User Reviews

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