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home > drugs a-z list > oforta (fludarabine phosphate tablets) drug center > oforta (fludarabine phosphate tablets) drug - overdosage and contraindications
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Oforta
Leukemia facts
- Leukemia is a cancer of the blood cells.
- While the exact cause(s) of leukemia is not known, risk factors have been identified.
- Leukemias are grouped by how quickly the disease develops (acute or chronic) as well as by the type of blood cell that is affected (lymphocytes or myelocytes). The four main types of leukemia include acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myelocytic leukemia (AML), and chronic myelocytic leukemia (CML).
- People with leukemia are at significantly increased risk for developing infections, anemia, and bleeding. Other symptoms and signs include easy bruising, weight loss, night sweats, and unexplained fevers.
- The diagnosis of leukemia is supported by findings of the
medical history and examination, and examining blood
and bone marrow samples under a microscope.
- Tre...
Oforta
OVERDOSE
High doses of fludarabine phosphate [See INDICATIONS AND USAGE and WARNINGS AND PRECAUTIONS] have been associated with an irreversible central nervous system toxicity characterized by delayed blindness, coma and death. High doses are also associated with severe thrombocytopenia and neutropenia due to bone marrow suppression. There is no known specific antidote for fludarabine phosphate overdosage. Treatment consists of drug discontinuation and supportive therapy. In Study 2, two patients ingested an overdose of 20% to 33% of Oforta™ (fludarabine phosphate tablets) . No serious side effects were reported.
CONTRAINDICATIONS
None
Last reviewed on RxList: 8/5/2009
This monograph has been modified to include the generic and brand name in many instances.
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