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Ogen

Last reviewed on RxList: 1/9/2017
Ogen Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 01/05/2017

Ogen (estropipate) is a natural estrogen (a female hormone) used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Ogen is also used to prevent osteoporosis. The brand name Ogen is discontinued, but generic versions may be available. Common side effects of Ogen (estropipate) include:

  • stomach upset,
  • nausea,
  • vomiting,
  • loss of appetite,
  • bloating,
  • breast tenderness or swelling,
  • headache or migraine,
  • weight changes,
  • acne or skin color changes,
  • decreased sex drive,
  • impotence,
  • difficulty having an orgasm,
  • dizziness,
  • vaginal pain/dryness/discomfort,
  • swelling of your ankles or feet,
  • depression,
  • changes in your menstrual periods, or
  • break-through bleeding.

Tell your doctor if you have serious side effects of Ogen (estropipate) including:

  • mental/mood changes (such as depression, memory loss),
  • breast lumps,
  • increased or new vaginal irritation/itching/odor/discharge,
  • severe stomach or abdominal pain,
  • persistent nausea or vomiting,
  • yellowing eyes or skin,
  • dark urine,
  • swelling hands/ankles/feet, or
  • increased thirst or urination.

The usual dose of Ogen is one .625 (0.75 mg estropipate) tablet to two 2.5 (3 mg estropipate) tablets per day. Ogen may interact with St. John's wort, phenobarbital, phenytoin, blood thinners, ritonavir, cimetidine, carbamazepine, rifampin, or antibiotics. Tell your doctor all medications and supplements you use. Ogen must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor. This medication passes into breast milk. It may reduce the quality and amount of breast milk produced. Consult your doctor before breastfeeding.

Our Ogen (estropipate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ogen Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden headache, confusion, problems with vision, speech, or balance;
  • pain or swelling in your lower leg;
  • abnormal vaginal bleeding;
  • pain, swelling, or tenderness in your stomach;
  • jaundice (yellowing of the skin or eyes); or
  • a lump in your breast.

Other less serious side effects are more likely to occur, such as:

  • nausea, vomiting, loss of appetite;
  • swollen breasts;
  • acne or skin color changes;
  • decreased sex drive, impotence, or difficulty having an orgasm;
  • migraine headaches or dizziness;
  • vaginal pain, dryness, or discomfort;
  • swelling of your ankles or feet;
  • depression; or
  • changes in your menstrual periods, break-through bleeding.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Ogen (Estropipate)

Ogen Professional Information

SIDE EFFECTS

See BOXED WARNINGS, WARNINGS, and PRECAUTIONS.

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of OGEN. Because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Genitourinary System

Abnormal uterine bleeding, dysmenorrhea or pelvic pain, increase in size of uterine leiomyomata; vaginitis (including vaginal candidiasis), change in cervical secretion, ovarian cancer, endometrial hyperplasia, endometrial cancer, leukorrhea.

Breasts

Tenderness, enlargement, pain, nipple discharge, galactorrhea, fibrocystic breast changes, breast cancer, gynecomastia in males.

Cardiovascular

Deep and superficial venous thrombosis, pulmonary embolism, thrombophlebitis, myocardial infarction, stroke, increase in blood pressure.

Gastrointestinal

Nausea, vomiting, abdominal cramps, bloating, cholestatic jaundice, increased incidence of gallbladder disease, pancreatitis, enlargement of hepatic hemangiomas, ischemic colitis.

Skin

Chloasma or melasma that may persist when drug is discontinued, erythema multiforme, erythema nodosum, loss of scalp hair, hirsutism, pruritus, rash.

Eyes

Retinal vascular thrombosis, intolerance to contact lenses.

Central Nervous System

Headache, migraine, dizziness, mental depression, nervousness, mood disturbances, irritability, exacerbation of epilepsy, dementia, possible growth potentiation of benign meningioma.

Miscellaneous

Increase or decrease in weight, glucose intolerance, aggravation of porphyria, edema, arthralgias, leg cramps, urticaria, angioedema, anaphylactoid/anaphylactic reactions, exacerbation of asthma, changes in libido, increased triglycerides.

Additional postmarketing adverse reactions have been reported in patients receiving other forms of hormone therapy.

Read the entire FDA prescribing information for Ogen (Estropipate)

Related Resources for Ogen

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© Ogen Patient Information is supplied by Cerner Multum, Inc. and Ogen Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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