Oleander

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Are there any interactions with medications?



Antibiotics (Macrolide antibiotics)
Interaction Rating: Major Do not take this combination.

Oleander can affect the heart. Some antibiotics might increase how much oleander the body absorbs. Increasing how much oleander the body absorbs might increase the effects and side effects of oleander.

Some antibiotics called macrolide antibiotics include erythromycin, azithromycin, and clarithromycin.



Antibiotics (Tetracycline antibiotics)
Interaction Rating: Major Do not take this combination.

Taking some antibiotics called tetracycline antibiotics along with oleander might increase the chance of side effects from oleander.

Some tetracycline antibiotics include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline (Achromycin).



Digoxin (Lanoxin)
Interaction Rating: Major Do not take this combination.

Digoxin (Lanoxin) helps the heart beat more strongly. Oleander also seems to affect the heart. Taking oleander along with digoxin can increase the effects of digoxin and increase the risk of side effects. Do not take oleander if you are taking digoxin (Lanoxin) without talking to your health care professional.



Quinine
Interaction Rating: Major Do not take this combination.

Oleander can affect the heart. Quinine can also affect the heart. Taking quinine along with oleander might cause serious heart problems.



Stimulant laxatives
Interaction Rating: Major Do not take this combination.

Oleander can affect the heart. The heart uses potassium. Laxatives called stimulant laxatives can decrease potassium levels in the body. Low potassium levels can increase the chance of side effects from taking oleander.

Some stimulant laxatives include bisacodyl (Correctol, Dulcolax), cascara, castor oil (Purge), senna (Senokot), and others.



Water pills (Diuretic drugs)
Interaction Rating: Major Do not take this combination.

Oleander might affect the heart. "Water pills" can decrease potassium in the body. Low potassium levels can also affect the heart and increase the risk of side effects from oleander.

Some "water pills" that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others.



Calcium supplements
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Oleander can stimulate the heartbeat. Calcium might also affect the heart. Taking oleander along with calcium might cause the heart to be too stimulated. Do not take oleander along with calcium supplements.

Dosing considerations for Oleander.

The appropriate dose of oleander depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for oleander. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


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