Omniscan (Gadodiamide) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

Pill Identifier Search

May 16, 2012

Omniscan

Adult Skin Problems Slideshow Pictures

How Smoking Affects Your Looks Slideshow Pictures

Weight Gain Shockers Slideshow

font size

OMNISCAN™
(gadodiamide) Injection for Intravenous Use

WARNING

NOT FOR INTRATHECAL USE and NEPHROGENIC SYSTEMIC FIBROSIS (NSF)

NOT FOR INTRATHECAL USE: Inadvertent intrathecal use of OMNISCAN (gadodiamide) has caused convulsions, coma, sensory and motor neurologic deficits [see WARNINGS AND PRECAUTIONS].

NSF:

Gadolinium-based contrast agents (GBCAs) increase the risk for NSF among patients with impaired elimination of the drugs. Avoid use of GBCAs in these patients unless the diagnostic information is essential and not available with non-contrasted MRI or other modalities. NSF may result in fatal or debilitating fibrosis affecting the skin, muscle and internal organs.
Do not administer OMNISCAN (gadodiamide) to patients with:
- chronic, severe kidney disease (GFR < 30 mL/min/1.73m²), or
- acute kidney injury [see CONTRAINDICATIONS].
Screen patients for acute kidney injury and other conditions that may reduce renal function. For patients at risk for chronically reduced renal function (e.g., age > 60 years, hypertension or diabetes), estimate the glomerular filtration rate (GFR) through laboratory testing.
Do not exceed the recommended OMNISCAN (gadodiamide) dose and allow a sufficient period of time for elimination of the drug from the body prior to any readministration [see WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION

OMNISCAN (gadodiamide) Injection is the formulation of the gadolinium complex of diethylenetriamine pentaacetic acid bismethylamide, and is an injectable, nonionic extracellular enhancing agent for magnetic resonance imaging.

OMNISCAN (gadodiamide) is administered by intravenous injection. OMNISCAN (gadodiamide) is provided as a sterile, clear, colorless to slightly yellow, aqueous solution. Each 1 mL contains 287 mg gadodiamide and 12 mg caldiamide sodium in Water for Injection. The pH is adjusted between 5.5 and 7.0 with hydrochloric acid and/or sodium hydroxide. OMNISCAN (gadodiamide) contains no antimicrobial preservative. OMNISCAN (gadodiamide) is a 0.5 mol/L solution of aqua[5,8-bis(carboxymethyl)11-[2-(methylamino)-2-oxoethyl]-3-oxo-2,5,8,11-tetraazatridecan-13-oato (3-)-N⁵, N⁸, N¹¹, O³, O⁵, O⁸, O¹¹, O¹³] gadolinium hydrate, with a molecular weight of 573.66 (anhydrous), an empirical formula of C₁₆H₂₈GdN₅O₉•xH₂O, and the following structural formula: