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home > drugs a-z list > oncaspar (pegaspargase) drug center > oncaspar (pegaspargase) drug - overdosage and contraindications
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Oncaspar
Leukemia facts
- Leukemia is a cancer of the blood cells.
- While the exact cause(s) of leukemia is not known, risk factors have been identified.
- Leukemias are grouped by how quickly the disease develops (acute or chronic) as well as by the type of blood cell that is affected (lymphocytes or myelocytes). The four main types of leukemia include acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myelocytic leukemia (AML), and chronic myelocytic leukemia (CML).
- People with leukemia are at significantly increased risk for developing infections, anemia, and bleeding. Other symptoms and signs include easy bruising, weight loss, night sweats, and unexplained fevers.
- The diagnosis of leukemia is supported by findings of the
medical history and examination, and examining blood
and bone marrow samples under a microscope.
- Tre...
Oncaspar
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OVERDOSE
Three patients received 10,000 IU/m2 of Oncaspar® (pegaspargase) as an intravenous infusion. One patient experienced a slight increase in liver enzymes. A second patient developed a rash 10 minutes after the start of the infusion, which was controlled with the administration of an antihistamine and by slowing down the infusion rate. A third patient did not experience any adverse reactions.
CONTRAINDICATIONS
- History of serious allergic reactions to Oncaspar® (pegaspargase)
- History of serious thrombosis with prior L-asparaginase I therapy
- History of pancreatitis with prior L-asparaginase therapy
- History of serious hemorrhagic events with prior L-asparaginase therapy
Last reviewed on RxList: 3/2/2009
This monograph has been modified to include the generic and brand name in many instances.
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