Brain & Nervous
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There are six types of generalized seizures. The most common and dramatic, and therefore the most well known, is the generalized convulsion, also called the grand-mal seizure. In this type of seizure, the patient loses consciousness and usually collapses. The loss of consciousness is followed by generalized body stiffening (called the "tonic" phase of the seizure) for 30 to 60 seconds, then by violent jerking (the "clonic" phase) for 30 to 60 seconds, after which the patient goes into a deep sleep (the "postictal" or after-seizure phase). During grand-mal seizures, injuries and accidents may occur, such as tongue biting and urinary incontinence.
Absence seizures cause a short loss of consciousness (just a few seconds) with few or no symptoms. The patient, most often a child, typically interrupts an activity and stares blankly. These seizures begin and end abruptly and may occur several times a day. Patients are usu...
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ONFI™
(clobazam) Tablets, for Oral Use
Table 4. Description
| Proprietary Name: | ONFIIM | |
| Established Name: | Clobazam | |
| Dosage Form: | Tablet | |
| Route of Administration: | Oral | |
| Pharmacologic Class of Drug: | Antiepileptic drug of the benzodiazepine class | |
| Chemical Name: | 7-Chloro-1-methyl-5-phenyl-1 H-1 ,5 benzodiazepine-2,4(3H,5H)-dione | |
Structural Formula:
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Each ONFI tablet contains 5 mg, 10 mg, or 20 mg of clobazam. Tablets also contain as inactive ingredients: corn starch, lactose monohydrate, magnesium stearate, silicon dioxide, and talc. The molecular formula is C16H13O2N2Cl and the molecular weight is 300.7.
Clobazam is a white or almost white, crystalline powder which is freely soluble in methylene chloride, slightly soluble in water, and sparingly soluble in ethanol. The melting range of clobazam is from 182-185°C.
Last reviewed on RxList: 10/31/2011
This monograph has been modified to include the generic and brand name in many instances.
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Find tips and treatments to control seizures.