Patients receiving OptiMARK™ (gadoversetamide injection) Injection should be instructed before injection to:

1. Inform their physician or health care provider if they are pregnant or breast feeding (see PRECAUTIONS, Pregnancy Category C and Nursing Mothers).
2. Inform their physician or health care provider if they have a history of renal and/or liver disease, anemia, hemoglobinopathies, or diseases that affect red blood cells.
3. Inform their physician or health care provider if they have a history of asthma or allergic respiratory disorders, seizures, or heart disease.
4. Inform their physician or health care provider of all medications they may be taking.
5. Inform their physician if they have recently received a GBCA.

GBCAs increase the risk for NSF among patients with impaired elimination of the drugs. To counsel patients at risk for NSF:

• Describe the clinical manifestations of NSF
• Describe procedures to screen for the detection of renal impairment

Instruct the patients to contact their physician if they develop signs or symptoms of NSF following OptiMARK™ (gadoversetamide injection) administration, such as burning, itching, swelling, scaling, hardening and tightening of the skin; red or dark patches on the skin; stiffness in joints with trouble moving, bending or straightening the arms, hands, legs or feet; pain in the hip bones or ribs; or muscle weakness.

Last reviewed on RxList: 2/11/2011
This monograph has been modified to include the generic and brand name in many instances.