"The cystic fibrosis (CF) drug Orkambi (Vertex Pharmaceuticals) has received a green light from the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP).
Orkambi is a fixed-dose oral combination "...
Clinical consequences of overdosage with OptiMARK have not been reported. Treatment of overdose is directed toward supporting vital functions and prompt institution of symptomatic therapy. OptiMARK has been shown to be dialyzable [see CLINICAL PHARMACOLOGY].
OptiMARK is contraindicated in patients with:
- chronic, severe kidney disease (glomerular filtration rate, GFR < 30 mL/min/1.73m²)
- acute kidney injury
- known hypersensitivity reactions to gadolinium, versetamide or any of the inert ingredients.
Last reviewed on RxList: 12/15/2014
Additional OptiMARK Information
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