No deaths due to acute poisoning with phentolamine have been reported. Overdosage with parenterally administered phentolamine is characterized chiefly by cardiovascular disturbances, such as arrhythmias, tachycardia, hypotension, and possibly shock. In addition, the following might occur: excitation, headache, sweating, pupillary contraction, visual disturbances, nausea, vomiting, diarrhea, or hypoglycemia.
There is no specific antidote; treatment consists of appropriate monitoring and supportive care. Substantial decreases in blood pressure or other evidence of shock-like conditions should be treated vigorous and promptly.
Oraverse is contraindicated in patients with: Hypersensitivity to the active substance or to any ingredients in the formulation.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 6/21/2016
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