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In this Article

• What is abatacept (Orencia)?
• What are the possible side effects of abatacept (Orencia)?
• What is the most important information I should know about abatacept (Orencia)?
• What should I discuss with my healthcare provider before using abatacept (Orencia)?
• How should I use abatacept (Orencia)?
• What happens if I miss a dose (Orencia)?
• What happens if I overdose (Orencia)?
• What should I avoid while using abatacept (Orencia)?
• What other drugs will affect abatacept (Orencia)?
• Where can I get more information?

What should I discuss with my healthcare provider before using abatacept (Orencia)?

You should not use this medication if you are allergic to abatacept, or if you are also using anakinra (Kineret), etanercept (Enbrel), adalimumab (Humira), or infliximab (Remicade).

Before using abatacept, tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

• a weak immune system;
• any type of infection including a skin infection or open sores;
• COPD (chronic obstructive pulmonary disease);
• diabetes;
• if you have ever had hepatitis; or
• if you are scheduled to receive any vaccines.

FDA pregnancy category B. Abatacept is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Your name may need to be listed on a pregnancy registry if you become pregnant while using this medication. The purpose of this registry is to track the outcome of the pregnancy and delivery to evaluate whether abatacept had any effect on the baby.

Abatacept can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Children using this medication should be current on all childhood immunizations before starting treatment with abatacept.

Using abatacept may increase your risk of developing certain types of cancer such as lymphoma (cancer of the lymph nodes). This risk may be greater in older adults. Talk to your doctor about your specific risk.

How should I use abatacept (Orencia)?

Before you start treatment with abatacept, your doctor may perform tests to make sure you do not have tuberculosis or other infections.

Abatacept is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to use your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles, IV tubing, and other items used in giving the medicine.

Abatacept must be given slowly through an IV infusion, and can take at least 30 minutes to complete. This medication is usually given every 2 to 4 weeks. Follow your doctor's instructions.

You will need to mix abatacept with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.

Each single-use vial (bottle) of this medicine is for one use only. Throw away the vial after one use, even if there is still some medicine left in it after injecting your dose.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using abatacept.

If you have chronic hepatitis B you may develop liver symptoms while using abatacept and even months after you stop using it. Your doctor may want to check your liver function at regular visits for up to several months after you stop using abatacept. Do not miss any scheduled appointments.

This medication can cause you to have false results with certain blood glucose tests, showing high blood sugar readings. If you have diabetes, talk to your doctor about the best way to check your blood sugar while you are using abatacept.

Autoimmune disorders are often treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

Store this medication in the refrigerator. Do not freeze. Keep the medicine in original carton to protect it from light. Do not use abatacept if the expiration date on the medicine label has passed.

Abatacept that has been mixed with a diluent may be stored in a refrigerator or at room temperature and used within 24 hours.

Do not shake the mixed medicine. Vigorous shaking can ruin the medicine. Do not use the medication if it has changed colors or appears cloudy. Call your doctor for a new prescription.