"Nov. 2, 2012 -- Safety steps taken in the wake of the fungal meningitis outbreak have worsened drug shortages, raising questions about whether the U.S. must choose between the safety and the availability of crucial medicines.
(orphenadrine citrate, aspirin and caffeine) Tablets 25 mg/385 mg/30 mg) and
Orphengesic Forte Tablets
(orphenadrine citrate, aspirin and caffeine) Tablets 50 mg/770 mg/60 mg
Each Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Tablet, for oral administration contains Orphenadrine Citrate 25mg, Aspirin 385mg and Caffeine 30 mg. Each Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Forte Tablet, fororaladministration contains OrphenadrineCitrate 50 mg, Aspirin 770 mg and Caffeine 60 mg.
In addition, each tablet contains the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, D&C yellow #10, FD&C blue #1, povi-done, pregelatinized starch, stearic acid, and zinc stearate.
Orphenadrine Citrate is (2-dimethylaminoethyl 2-methyl-benzhydryl ether citrate). It is a white, practically odorless, crystalline powder, having a bitter taste. It is sparingly soluble in water, slightly soluble in alcohol. It has the following structural formula:
C18H23NO•C6H8O7 MW 461.51
Aspirin, salicylic acid acetate, is a non-opiate analgesic, anti-inflammatory and anti-pyretic agent. It occurs as a white, crystalline tabular or needle-like powder and is odorless or has a faint odor. It is sparingly soluble in water, freely soluble in alcohol and chloroform. It has the following structural formula:
Caffeine is a central nervous system stimulant which occurs as a white powder or white glistening needles, usually matted together. It is sparingly soluble in alcohol, and freely soluble in chloroform. The chemical name forcaffeineis, 1,3,7-Trimethylxanthine. It has thefollowing structural formula:
Last reviewed on RxList: 12/17/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Orphengesic Information
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