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Orphengesic

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Orphengesic

CLINICAL PHARMACOLOGY

Orphenadrine citrate is a cen-trallyacting(brain stem) compound which in animals selectively blocks facilitatory functions of the reticularformation. Orphenadrine does not produce myoneural block, nor does it affect crossed extensor reflexes. Orphenadrine prevents nicotine-induced convulsions but not those pro-ducedby strychnine.

Chronic administration of Or-phenadrine Citrate, Aspirin and Caffeine to dogsandratshas revealed no drug-related toxi-city. Nobloodorurine changes were observed, nor were there any macroscopic or microscopic pathological changes detected. Extensive experience with combinations containing aspirin and caffeine hasestablished them as safe agents. The addition oforphen-adrine citrate does not alter the toxicity of aspirin and caffeine.

The mode of therapeutic action of orphenadrine has not been clearly identified, but may be related to its analgesic prop-erties. Orphenadrine citrate also possesses anti-cholinergic actions.

Last reviewed on RxList: 12/17/2008
This monograph has been modified to include the generic and brand name in many instances.

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