"Consumers and health care professionals will soon find updated labeling for extended-release and long-acting opioid pain relievers to help ensure their safe and appropriate use.
In addition to requiring new labeling on these prescript"...
Orphenadrine citrate is a cen-trallyacting(brain stem) compound which in animals selectively blocks facilitatory functions of the reticularformation. Orphenadrine does not produce myoneural block, nor does it affect crossed extensor reflexes. Orphenadrine prevents nicotine-induced convulsions but not those pro-ducedby strychnine.
Chronic administration of Or-phenadrine Citrate, Aspirin and Caffeine to dogsandratshas revealed no drug-related toxi-city. Nobloodorurine changes were observed, nor were there any macroscopic or microscopic pathological changes detected. Extensive experience with combinations containing aspirin and caffeine hasestablished them as safe agents. The addition oforphen-adrine citrate does not alter the toxicity of aspirin and caffeine.
Last reviewed on RxList: 12/17/2008
This monograph has been modified to include the generic and brand name in many instances.
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