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Reye's Syndrome may develop inindividualswhohave chicken pox, influenza, orflusymp-toms. Some studies suggest a possible association between the developmentof Reye's Syndrome and the use of medicines containing salicylate or aspirin. Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Tablets (Orphenadrine Citrate, Aspirin and Caffeine Tablets 25mg/ 385mg/30 mg) and Orphen-gesic Forte Tablets (Orphen-adrine Citrate, Aspirin andCaf-feine Tablets 50 mg/770 mg/ 60 mg) contain aspirin and therefore are not recommended for use in patients with chicken pox, influenza, orflu symptoms.

Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Tablets and Or-phengesic Forte Tablets may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle; ambulatory patients should therefore be cautioned accordingly.

Aspirin should be used with extreme caution in the presence of peptic ulcers andcoag-ulationabnormalities.

Usage in Pregnancy: Since safety of the use of this preparation in pregnancy, during lactation, or in the childbearing age has not been established, use of the drug in such patients requires that the potentialben-efits of the drug be weighed against its possible hazard to the mother and child.

Usage in Children: The safe and effective use of this drug in children has not been established. Usage of this drug in children under 12 years of age is not recommended.


Confusion, anxiety and tremors have been reportedin a few patients receiving propoxyphene and orphena-drineconcomitantly. Asthese symptoms may be simply due to an additive effect, reduction of dosage and/or discontinuation of one or both agents is recommended in such cases.

Safety of continuous long term therapy with Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Tablets and Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Forte Tablets has not been established; therefore, if Orphen-gesic Tablets or Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Forte Tablets are prescribed for prolonged use, periodic monitoringof blood, urine and liver function values is recommended.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 12/17/2008


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