August 24, 2016
Recommended Topic Related To:


"The U.S. Food and Drug Administration today approved Hysingla ER (hydrocodone bitartrate), an extended-release (ER) opioid analgesic to treat pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternat"...



Orphengesic Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 5/06/2016

Orphengesic (orphenadrine citrate, aspirin and caffeine) is a combination muscle relaxant, pain reliever, and stimulant used for relief of mild to moderate pain of acute musculoskeletal disorders. Orphengesic is also used as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. The brand name Orphengesic is discontinued, but generic versions may be available. Common side effects of Orphengesic (orphenadrine citrate, aspirin and caffeine) include:

The adult dose of Orphengesic is 1/2 to 1 tablet 3 to 4 times daily. Orphengesic may interact with other drugs. Tell your doctor all medications and supplements you use. It is unknown if Orphengesic could be harmful to a fetus, Tell your doctor if you are pregnant or plan to become pregnant before starting treatment. Consult your doctor before breastfeeding.

Our Orphengesic (orphenadrine citrate, aspirin and caffeine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Orphengesic FDA Prescribing Information: Side Effects
(Adverse Reactions)


Side effects of Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Tablets or Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Forte Tablets are those seen with aspirin and caffeine or those usually associated with mild anticholinergic agents. These may include tachycardia, palpitation, urinary hesitancy or retention, dry mouth, blurred vision, dilatation of the pupil, increased intraocular tension, weakness, nausea, vomiting, headache, dizziness, constipa-tion, drowsiness, and rarely, urticaria and other derma-toses. Infrequently, an elderly patientmayexperiencesome degree of confusion. Mild central excitation and occasional hallucinations may be ob-served. These mild side effects can usually be eliminated by reduction in dosage. One case of aplastic anemia associated with the use of orphenadrine citrate, aspirin and caffeine has been reported. Nocasual relationship has been established. Rare G.I. hemorrhage due to aspirin content may be associated with the administration of Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Tablets or Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Forte Tablets. Somepatients may experience transient episodes of lightheadedness, dizziness or syncope.

Read the entire FDA prescribing information for Orphengesic (Orphenadrine Citrate, Asprin and Caffeine Tablets)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Chronic Pain/Back Pain

Find tips and advances in treatment.

Health Resources
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations