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Adverse reactions reported with the use of POPs include:
- Menstrual irregularity is the most frequently reported side effect.
- Frequent and irregular bleeding are common, while long duration of bleeding episodes and amenorrhea are less likely.
- Headache, breast tenderness, nausea, and dizziness are increased among progestin-only oral contraceptive users in some studies.
- Androgenic side effects such as acne, hirsutism, and weight gain occur rarely.
Read the Ortho Micronor (norethindrone) Side Effects Center for a complete guide to possible side effects
The effectiveness of progestin-only pills is reduced by hepatic enzyme-inducing drugs such as the anticonvulsants phenytoin, carbamazepine, and barbiturates, and the antituberculosis drug rifampin. No significant interaction has been found with broad-spectrum antibiotics.
Interactions with Laboratory Tests
The following endocrine tests may be affected by progestin-only oral contraceptive use:
- Sex hormone-binding globulin (SHBG) concentrations may be decreased.
- Thyroxine concentrations may be decreased, due to a decrease in thyroid binding globulin (TBG).
Read the Ortho Micronor Drug Interactions Center for a complete guide to possible interactions
Last reviewed on RxList: 7/24/2008
This monograph has been modified to include the generic and brand name in many instances.
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