Ovarian Cancer (cont.)
Melissa Conrad Stöppler, MD
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
In this Article
- What is ovarian cancer?
- Epithelial ovarian cancer
- Borderline ovarian tumors
- Germ cell ovarian cancers
- Stromal ovarian cancers
- The statistics for ovarian cancer
- What are the risk factors for ovarian cancer?
- What are ovarian cancer symptoms and signs?
- How is ovarian cancer diagnosed?
- How is ovarian cancer staging determined?
- What is the treatment for ovarian cancer?
- What is the survival rate and prognosis of ovarian cancer?
- Can ovarian cancer be prevented?
- Pictures of Ovarian Cancer - Slideshow
- Take the Ovarian Cancer Quiz
- 15 Cancer Symptoms Women Ignore - Slideshow
- Ovarian Cancer FAQs
- Find a local Oncologist in your town
How is ovarian cancer staging determined?
Staging is the process of classifying a tumor according to the extent to which it has spread in the body at the time of diagnosis.
Ovarian cancer staging:
- Stage 1: Limited to one or both ovaries
- Stage 2: Limited to disease in the pelvis
- Stage 3: Disease outside of the pelvis, but limited to the abdomen, or lymph node involvement, but not including the inside of the liver
- Stage 4: Disease spread to the liver or outside of the abdomen
Complete staging of an ovarian cancer includes hysterectomy, removal of the ovaries, tubes, pelvic and aortic lymph node biopsies or dissection, the omentum (a large fatty structure that provides support for abdominal organs), and peritoneal (lining tissue of the abdomen) biopsies.
Ovarian cancer staging is determined surgically, unless it is stage 4 (metastasis outside of the abdomen, or metastasis to the liver -- not on the surface of the liver). If it is stage 4, or very advanced stage 3, then often this is proven with biopsy, and chemotherapy is begun neoadjuvantly (before surgery). If the disease does not present with obvious stage 4 disease, then aggressive surgical staging and debulking (see next section) is often considered. This decision is based on the health of the patient, as well as the judgment of the surgeon as to the chance of achieving an optimal debulking (see treatment below).
If medically feasible, apparent early stage cancers should be staged thoroughly. This is due to the fact that of clinical stage 1 tumors, greater than 30% will have metastatic disease on formal staging. This knowledge can lead to treatment recommendations that might not otherwise be made.
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