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Oxacillin

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Oxacillin

Oxacillin
(oxacillin (oxacillin (oxacillin for injection) for injection) ) Injection, Solution
in Plastic Container

For Intravenous Use Only

GALAXY Container (PL 2040)

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Oxacillin Injection, USP and other antibacterial drugs, Oxacillin (oxacillin (oxacillin for injection) for injection) Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Oxacillin

DRUG DESCRIPTION

Oxacillin Injection, USP is a sterile injectable product containing oxacillin which is added as oxacillin (oxacillin (oxacillin for injection) for injection) sodium, a semisynthetic penicillin derived from the penicillin nucleus, 6-aminopenicillanic acid. The chemical name of oxacillin (oxacillin (oxacillin for injection) for injection) sodium is 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3- dimethyl-6-[[(5-methyl-3-phenyl-4- isoxazolyl)carbonyl]-amino]-7-oxo-, monosodium salt, monohydrate, [2S-(2α,5α,6β)]-. It is resistant to inactivation by the enzyme penicillinase (beta-lactamase). The molecular formula of oxacillin (oxacillin (oxacillin for injection) for injection) sodium is C19H18N3NaO5S•H2O. The molecular weight is 441.44.

The structural formula of oxacillin (oxacillin (oxacillin for injection) for injection) sodium is as follows:

Oxacillin Structural Formula Illustration

Oxacillin (oxacillin (oxacillin for injection) for injection) Injection, USP is a frozen, iso-osmotic, sterile, nonpyrogenic premixed 50 mL solution containing 1 g or 2 g of oxacillin added as oxacillin (oxacillin (oxacillin for injection) for injection) sodium. Dextrose, USP has been added to the above dosages to adjust osmolality (approximately 1.5 g and 300 mg as dextrose hydrous to the 1 g and 2 g dosages respectively). Sodium Citrate Hydrous, USP has been added as a buffer (approximately 150 mg and 300 mg to the 1 g and 2 g dosages, respectively). The pH has been adjusted with hydrochloric acid and may have been adjusted with sodium hydroxide. The pH is 6.5 (6.0 to 8.5). The solution is intended for intravenous use after thawing to room temperature.

This GALAXY container (PL 2040) is fabricated from a specially designed multilayer plastic (PL 2040). Solutions are in contact with the polyethylene layer of this container and can leach out certain chemical components of the plastic in very small amounts within the expiration period. The suitability of the plastic has been confirmed in tests in animals according to the USP biological tests for plastic containers, as well as by tissue culture toxicity studies.

What are the possible side effects of oxacillin (Bactocill)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • diarrhea that is watery or bloody;
  • fever, chills, body aches, flu symptoms;
  • easy bruising or bleeding, unusual weakness;
  • urinating less than usual or not at all;
  • severe skin rash, itching, or...

Read All Potential Side Effects and See Pictures of Oxacillin »

What are the precautions when taking oxacillin for injection (Oxacillin )?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies. This product may contain inactive ingredients (such as corn for products containing dextrose), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, kidney disease, liver disease.

This medication contains sodium. This could affect you if you are on a salt-restricted diet or if you have a condition which could be worsened with an increase in salt intake (e.g., congestive heart failure). Consult your doctor or pharmacist for more information.

Kidney...

Read All Potential Precautions of Oxacillin »

Last reviewed on RxList: 8/26/2008
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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