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Oxacillin Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Oxacillin (Brand name: Bactocil) is a penicillin-type antibiotic used to treat many different types of infections caused by bacteria, such as a staphylococcal (also called "staph") infection. Oxacillin is available in generic form. Common side effects of Oxacillin include pain at the injection site if injected into a muscle, nausea, vomiting, stomach pain, vaginal itching or discharge, headache, swollen/black/"hairy" tongue, or thrush (white patches or inside your mouth or throat).
For mild to moderate infections, the dose of oxacillin is 250-500 mg administered intravenously every 4-6 hours. For severe infections, 1g is administered intravenously every 4-6 hours. Oxacillin may interact with methotrexate or probenecid. Tell your doctor all medications you use. During pregnancy, oxacillin should be used only when prescribed. This drug passes into breast milk. Consult your doctor before breastfeeding.
Our Oxacillin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Oxacillin in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
- diarrhea that is watery or bloody;
- fever, chills, body aches, flu symptoms;
- easy bruising or bleeding, unusual weakness;
- urinating less than usual or not at all;
- severe skin rash, itching, or peeling;
- agitation, confusion, unusual thoughts or behavior; or
- seizure (black-out or convulsions).
Less serious side effects may include:
- nausea, vomiting, stomach pain;
- vaginal itching or discharge;
- swollen, black, or "hairy" tongue; or
- thrush (white patches or inside your mouth or throat).
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Oxacillin (Oxacillin for Injection)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Oxacillin Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: pain/swelling at injection site (if this drug is injected into a vein), joint/muscle pain, dark/cloudy urine, change in the amount of urine, severe abdominal/stomach pain, yellowing eyes/skin, persistent nausea/vomiting, extreme tiredness, easy bruising/bleeding, new signs of infection (e.g., fever, persistent sore throat), seizures, uncontrolled movements, confusion.
This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.
Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Oxacillin (Oxacillin for Injection)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Oxacillin FDA Prescribing Information: Side Effects
Body as a Whole
The reported incidence of allergic reactions to penicillin ranges from 0.7 to 10 percent (see WARNINGS). Sensitization is usually the result of treatment but some individuals have had immediate reactions when first treated. In such cases, it is thought that the patients may have had prior exposure to the drug via trace amounts present in milk and vaccines.
Two types of allergic reactions to penicillins are noted clinically, immediate and delayed.
Immediate reactions usually occur within 20 minutes of administration and range in severity from urticaria and pruritus to angioneurotic edema, laryngospasm, bronchospasm, hypotension, vascular collapse and death. Such immediate anaphylactic reactions are very rare (see WARNINGS) and usually occur after parenteral therapy but have occurred in patients receiving oral therapy. Another type of immediate reaction, an accelerated reaction, may occur between 20 minutes and 48 hours after administration and may include urticaria, pruritus, and fever. Although laryngeal edema, laryngospasm, and hypotension occasionally occur, fatality is uncommon. Delayed allergic reactions to penicillin therapy usually occur after 48 hours and sometimes as late as 2 to 4 weeks after initiation of therapy.
Manifestations of this type of reaction include serum sickness-like symptoms (i.e., fever, malaise, urticaria, myalgia, arthralgia, abdominal pain) and various skin rashes. Nausea, vomiting, diarrhea, stomatitis, black or hairy tongue, and other symptoms of gastrointestinal irritation may occur, especially during oral penicillin therapy.
Nervous System Reactions
Neurotoxic reactions similar to those observed with penicillin G may occur with large intravenous doses of oxacillin (oxacillin (oxacillin for injection) for injection) , especially with patients with renal insufficiency.
Renal tubular damage and interstitial nephritis have been associated infrequently with the administration of oxacillin (oxacillin (oxacillin for injection) for injection) . Manifestations of this reaction may include rash, fever, eosinophilia, hematuria, proteinuria, and renal insufficiency.
Pseudomembranous colitis has been reported with the use of oxacillin (oxacillin (oxacillin for injection) for injection) . The onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment (see WARNINGS).
Hepatotoxicity, characterized by fever, nausea, and vomiting associated with abnormal liver function tests, mainly elevated SGOT levels, has been associated with the use of oxacillin (oxacillin (oxacillin for injection) for injection) .
Read the entire FDA prescribing information for Oxacillin (Oxacillin for Injection)
Additional Oxacillin Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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