"Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as the sensation of itch.
(oxiconazole nitrate cream) Cream, 1%*
(oxiconazole nitrate lotion) Lotion, 1%*
*Potency expressed as oxiconazole
OXISTAT (oxiconazole) Cream and Lotion formulations contain the antifungal active compound oxiconazole nitrate. Both formulations are for topical dermatologic use only.
Chemically, oxiconazole nitrate is 2',4'-dichloro-2-imidazol-1-ylacetophenone (Z)-[0-(2,4-dichlorobenzyl)oxime], mononitrate. The compound has the empirical formula C18H13ON3Cl4•HNO3, a molecular weight of 492.15, and the following structural formula:
OXISTAT Cream contains 10 mg of oxiconazole per gram of cream in a white to off-white, opaque cream base of purified water USP, white petrolatum USP, stearyl alcohol NF, propylene glycol USP, polysorbate 60 NF, cetyl alcohol NF, and benzoic acid USP 0.2% as a preservative.
OXISTAT Lotion contains 10 mg of oxiconazole per gram of lotion in a white to off-white, opaque lotion base of purified water USP, white petrolatum USP, stearyl alcohol NF, propylene glycol USP, polysorbate 60 NF, cetyl alcohol NF, and benzoic acid USP 0.2% as a preservative.
What are the possible side effects of oxiconazole topical (Oxistat)?
Serious side effects of oxiconazole topical use are not expected. Stop using oxiconazole and see your doctor if you experience unusual or severe blistering, itching, redness, peeling, dryness, or irritation of the skin.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at...
What are the precautions when taking oxiconazole (Oxistat)?
Before using oxiconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals such as clotrimazole, ketoconazole, or miconazole; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history.
This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor.
This medication passes into breast milk. Consult your doctor before...
Last reviewed on RxList: 5/5/2008
This monograph has been modified to include the generic and brand name in many instances.
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