Oxytrol
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Oxytrol
OXYTROL®
(oxybutynin) Transdermal System
DRUG DESCRIPTION
OXYTROL (oxybutynin) Transdermal System is designed to deliver oxybutynin over a 3- to 4day interval after application to intact skin. OXYTROL is available as a 39 cm² system containing 36 mg of oxybutynin. OXYTROL has a nominal in vivo delivery rate of 3.9 mg oxybutynin per day through skin of average permeability (inter-individual variation in skin permeability is approximately 20%).
Oxybutynin is an antispasmodic, anticholinergic agent. Oxybutynin is administered as a racemate of R- and S-isomers. Chemically, oxybutynin is d, l (racemic) 4-diethylamino-2butynyl phenylcyclohexylglycolate. The empirical formula of oxybutynin is C22H31NO3. Its structural formula is:
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Oxybutynin is a white powder with a molecular weight of 357. It is soluble in alcohol, but relatively insoluble in water.
OXYTROL is a matrix-type transdermal system composed of three layers as illustrated in Figure 1. Layer 1 (Backing Film) is a thin flexible polyester/ethylene-vinyl acetate film that provides the matrix system with occlusivity and physical integrity and protects the adhesive/drug layer. Layer 2 (Adhesive/Drug Layer) is a cast film of acrylic adhesive containing oxybutynin and triacetin, USP. Layer 3 (Release Liner) is two overlapped siliconized polyester strips that are peeled off and discarded by the patient prior to applying the matrix system.
Figure 1: Side and top views of
the OXYTROL system. (Not to scale)
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What are the possible side effects of oxybutynin transdermal (Oxytrol)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using oxybutynin transdermal and call your doctor at once if you have a serious side effect such as:
- fever with hot, dry skin;
- uneven heart rate;
- pain or burning when you urinate;
- urinating less than usual or not at all; or
- severe itching, burning, or blistering that does not clear up within several hours after removing the skin patch.
Less serious...
Read All Potential Side Effects and See Pictures of Oxytrol »
What are the precautions when taking oxybutynin transdermal (Oxytrol)?
Before using oxybutynin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: active internal bleeding, severe blockage/slowed movement of the stomach/intestines (e.g., gastric retention, paralytic ileus), certain bladder problems (urinary retention), uncontrolled glaucoma (narrow-angle).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: other bladder problems (bladder outflow obstruction), certain...
Last reviewed on RxList: 10/18/2012
This monograph has been modified to include the generic and brand name in many instances.
Additional Oxytrol Information
Oxytrol - User Reviews
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