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*Urinary incontinence (UI) in men facts Medically Edited by: Melissa Conrad Stöppler, MD
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OXYTROL®
(oxybutynin) Transdermal System
OXYTROL, oxybutynin transdermal system, is designed to deliver oxybutynin continuously and consistently over a 3- to 4-day interval after application to intact skin.
OXYTROL is available as a 39 cm² system containing 36 mg of oxybutynin.
OXYTROL has a nominal in vivo delivery rate of 3.9 mg oxybutynin per day through skin of average permeability (interindividual variation in skin permeability is approximately 20%).
Oxybutynin is an antispasmodic, anticholinergic agent. Oxybutynin is administered as a racemate of R- and S-isomers. Chemically, oxybutynin is d, l (racemic) 4-diethylamino2-butynyl phenylcyclohexylglycolate. The empirical formula of oxybutynin is C22H31NO3. Its structural formula is:
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Oxybutynin is a white powder with a molecular weight of 357. It is soluble in alcohol, but relatively insoluble in water.
OXYTROL (oxybutynin transdermal) is a matrix-type transdermal system composed of three layers as illustrated in Figure 1 below. Layer 1 (Backing Film) is a thin flexible polyester/ethylene-vinyl acetate film that provides the matrix system with occlusivity and physical integrity and protects the adhesive/drug layer. Layer 2 (Adhesive/Drug Layer) is a cast film of acrylic adhesive containing oxybutynin and triacetin, USP. Layer 3 (Release Liner) is two overlapped siliconized polyester strips that are peeled off and discarded by the patient prior to applying the matrix system.
Figure 1: Side and top views of the OXYTROL (oxybutynin transdermal) system. (Not to scale)
Side View
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Top View
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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using oxybutynin transdermal and call your doctor at once if you have any of these serious side effects:
Read All Potential Side Effects and See Pictures of Oxytrol »
Before using oxybutynin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: active internal bleeding, severe blockage/slowed movement of the stomach/intestines (e.g., gastric retention, paralytic ileus), certain bladder problems (urinary retention), uncontrolled glaucoma (narrow-angle).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: other bladder problems (bladder outflow obstruction), certain...
Last reviewed on RxList: 3/18/2011
This monograph has been modified to include the generic and brand name in many instances.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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