Oxytrol (Oxybutynin Transdermal) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Oxytrol

Urinary Incontinence »

Urinary incontinence (UI) in men facts

*Urinary incontinence (UI) in men facts Medically Edited by: Melissa Conrad Stöppler, MD

The definition of urinary incontinence in men is the unintentional loss of urine. Weak bladder muscles, overactive bladder muscles, certain prostate conditions, and nerve damage are just some of the possible underlying causes of urinary incontinence in men.
There are different types of urinary incontinence in men, including stress incontinence, urge incontinence, and overflow incontinence.
Diagnosis of urinary incontinence in men may involve a physical exam, an ultrasound, urodynamic testing, and tests including an electroencephalogram (EEG) and an electromyogram (EMG). The doctor will also take a medical history and may recommend keeping a bladder diary.
Treatment of urinary incontinence in men may include behavioral treatments, like bladder training and Kegel exercises, medication, surgery, or...

Read the Urinary Incontinence article »

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Oxytrol

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OXYTROL®
(oxybutynin) Transdermal System

DRUG DESCRIPTION

OXYTROL, oxybutynin transdermal system, is designed to deliver oxybutynin continuously and consistently over a 3- to 4-day interval after application to intact skin.

OXYTROL is available as a 39 cm² system containing 36 mg of oxybutynin.

OXYTROL has a nominal in vivo delivery rate of 3.9 mg oxybutynin per day through skin of average permeability (interindividual variation in skin permeability is approximately 20%).

Oxybutynin is an antispasmodic, anticholinergic agent. Oxybutynin is administered as a racemate of R- and S-isomers. Chemically, oxybutynin is d, l (racemic) 4-diethylamino2-butynyl phenylcyclohexylglycolate. The empirical formula of oxybutynin is C₂₂H₃₁NO₃. Its structural formula is:

OXYTROL® (Oxybutynin) Structural Formula Illustration

Oxybutynin is a white powder with a molecular weight of 357. It is soluble in alcohol, but relatively insoluble in water.

Transdermal System Components

OXYTROL (oxybutynin transdermal) is a matrix-type transdermal system composed of three layers as illustrated in Figure 1 below. Layer 1 (Backing Film) is a thin flexible polyester/ethylene-vinyl acetate film that provides the matrix system with occlusivity and physical integrity and protects the adhesive/drug layer. Layer 2 (Adhesive/Drug Layer) is a cast film of acrylic adhesive containing oxybutynin and triacetin, USP. Layer 3 (Release Liner) is two overlapped siliconized polyester strips that are peeled off and discarded by the patient prior to applying the matrix system.

Figure 1: Side and top views of the OXYTROL (oxybutynin transdermal) system. (Not to scale)
Side View

Side view of the OXYTROL system - Illustration

Top View

What are the possible side effects of oxybutynin transdermal (Oxytrol)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using oxybutynin transdermal and call your doctor at once if you have any of these serious side effects:

fever with hot, dry skin;
uneven heart rate;
pain, burning, or other difficulty when urinating; or
severe itching, burning, or blistering that does not clear up within several hours after removing the skin...

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What are the precautions when taking oxybutynin transdermal (Oxytrol)?

Before using oxybutynin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: active internal bleeding, severe blockage/slowed movement of the stomach/intestines (e.g., gastric retention, paralytic ileus), certain bladder problems (urinary retention), uncontrolled glaucoma (narrow-angle).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other bladder problems (bladder outflow obstruction), certain...

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Last reviewed on RxList: 3/18/2011
This monograph has been modified to include the generic and brand name in many instances.