"In a traditional corneal transplant, the central part of the cornea is removed and a donor cornea is sutured in its place. Image courtesy of Dr. Edward Holland, University of Cincinnati.
Ten years after a transplant, a cornea fro"...
(dexamethasone) Intravitreal Implant
OZURDEX® is an intravitreal implant containing 0.7 mg (700 mcg) dexamethasone in the NOVADUR® solid polymer sustained-release drug delivery system. OZURDEX® is preloaded into a single-use, DDS® applicator to facilitate injection of the rod-shaped implant directly into the vitreous. The NOVADUR® system contains poly (D,L-lactide-co-glycolide) PLGA intravitreal polymer matrix without a preservative. The chemical name for dexamethasone is Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16α)-. Its structural formula is:
MW 392.47; molecular formula: C22H29FO5
Dexamethasone occurs as a white to cream-colored crystalline powder having not more than a slight odor, and is practically insoluble in water and very soluble in alcohol.
The PLGA matrix slowly degrades to lactic acid and glycolic acid.
What are the possible side effects of dexamethasone intravitreal implant (Ozurdex)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- blurred vision, eye pain, or seeing halos around lights;
- eye redness, increased sensitivity of your eyes to light; or
- vision changes.
Less serious side effects may include blurred vision.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice...
Last reviewed on RxList: 11/10/2014
This monograph has been modified to include the generic and brand name in many instances.
Additional Ozurdex Information
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