August 29, 2015
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Pamelor

"April 8, 2015 -- A new study ties antidepressants to a higher risk for first-time seizures in people being treated for depression.

Older antidepressants called tricyclics were the only type not linked to the raised risk, say researchers fro"...

Pamelor




CLINICAL PHARMACOLOGY

The mechanism of mood elevation by tricyclic antidepressants is at present unknown. Pamelor is not a monoamine oxidase inhibitor. It inhibits the activity of such diverse agents as histamine, 5-hydroxytryptamine, and acetylcholine. It increases the pressor effect of norepinephrine but blocks the pressor response of phenethylamine. Studies suggest that Pamelor interferes with the transport, release, and storage of catecholamines. Operant conditioning techniques in rats and pigeons suggest that Pamelor has a combination of stimulant and depressant properties.

Last reviewed on RxList: 7/24/2014
This monograph has been modified to include the generic and brand name in many instances.

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