February 21, 2017
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Pamelor

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Pamelor




Pamelor Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 11/07/2016

Pamelor (nortriptyline HCl) is an antidepressant that is used to treat mental/mood problems such as depression. Common side effects of Pamelor include:

  • fast heart rate,
  • blurred vision,
  • urinary retention,
  • dry mouth,
  • constipation,
  • weight gain or loss,
  • dizziness upon standing (orthostatic hypotension),
  • tingly feeling,
  • weakness,
  • lack of coordination,
  • unpleasant taste,
  • nausea,
  • ringing in your ears,
  • breast swelling (in men or women),
  • decreased sex drive,
  • impotence, or
  • difficulty having an orgasm.

Tell the doctor immediately if you notice any of these side effects of Pamelor, especially worsening of depression or other psychiatric conditions.

Pamelor is administered orally in the form of capsules or liquid. Lower than usual dosages are recommended for elderly patients and adolescents. Pamelor may interact with other drugs that make you sleepy or slow your breathing (sleeping pills, narcotic pain medicines, muscle relaxers, or medicines for anxiety, depression, or seizures), bupropion, cimetidine, reserpine, St. John's wort, terbinafine, other antidepressants or medication to treat mental illness, bladder or urinary medicines, bronchodilators, cold or allergy medicines that contain an antihistamine, medications for Parkinson's disease; medications to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome; decongestants, diet pills, stimulants, or heart rhythm medications. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while using Pamelor; it is unknown if it will harm a fetus. It is unknown if Pamelor passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our Pamelor Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Pamelor in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • a feeling like you might pass out;
  • new or worsening chest pain, pounding heartbeats or fluttering in your chest;
  • sudden numbness or weakness, problems with vision, speech, or balance;
  • fever, sore throat;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • agitation, hallucinations, overactive reflexes, confusion, unusual thoughts or behavior;
  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • painful or difficult urination;
  • seizure (convulsions); or
  • upper stomach pain, loss of appetite, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • tingly feeling, weakness, lack of coordination;
  • dry mouth, unpleasant taste, nausea, constipation;
  • blurred vision, ringing in your ears;
  • breast swelling (in men or women); or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Pamelor (Nortriptyline HCl)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Pamelor FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Note

Included in the following list are a few adverse reactions that have not been reported with this specific drug. However, the pharmacologic similarities among the tricyclic antidepressant drugs require that each of the reactions be considered when nortriptyline is administered.

Cardiovascular

Hypotension, hypertension, tachycardia, palpitation, myocardial infarction, arrhythmias, heart block, stroke.

Psychiatric

Confusional states (especially in the elderly) with hallucinations, disorientation, delusions; anxiety, restlessness, agitation; insomnia, panic, nightmares; hypomania; exacerbation of psychosis.

Neurologic

Numbness, tingling, paresthesias of extremities; incoordination, ataxia, tremors; peripheral neuropathy; extrapyramidal symptoms; seizures, alteration in EEG patterns; tinnitus.

Anticholinergic

Dry mouth and, rarely, associated sublingual adenitis; blurred vision, disturbance of accommodation, mydriasis; constipation, paralytic ileus; urinary retention, delayed micturition, dilation of the urinary tract.

Allergic

Skin rash, petechiae, urticaria, itching, photosensitization (avoid excessive exposure to sunlight); edema (general or of face and tongue), drug fever, cross-sensitivity with other tricyclic drugs.

Hematologic

Bone marrow depression, including agranulocytosis; eosinophilia; purpura; thrombocytopenia.

Gastrointestinal

Nausea and vomiting, anorexia, epigastric distress, diarrhea, peculiar taste, stomatitis, abdominal cramps, blacktongue.

Endocrine

Gynecomastia in the male, breast enlargement and galactorrhea in the female; increased or decreased libido, impotence; testicular swelling; elevation or depression of blood sugar levels; syndrome of inappropriate ADH (antidiuretic hormone) secretion.

Other

Jaundice (simulating obstructive), altered liver function; weight gain or loss; perspiration; flushing; urinary frequency, nocturia; drowsiness, dizziness, weakness, fatigue; headache; parotid swelling; alopecia.

Withdrawal Symptoms

Though these are not indicative of addiction, abrupt cessation of treatment after prolonged therapy may produce nausea, headache, and malaise.

Read the entire FDA prescribing information for Pamelor (Nortriptyline HCl)

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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