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Antidepressants are a class of drugs that reduce symptoms of depressive disorders by correcting chemical imbalances of neurotransmitters in the brain. Chemical imbalances may be respo"...
Pamelor Side Effects Center
Medical Editor: Melissa Conrad Stöppler, MD
Pamelor (nortriptyline HCl) is an antidepressant that is used to treat mental/mood problems such as depression. Some common side effects associated with Pamelor may include fast heart rate, blurred vision, urinary retention, dry mouth, constipation, weight gain or loss, and orthostatic hypotension. Tell the doctor immediately if you notice any of these side effects especially worsening of depression or other psychiatric conditions. This is not a complete list of side effects, and others may occur.
Pamelor is administered orally in the form of capsules or liquid. Lower than usual dosages are recommended for elderly patients and adolescents. Drug interactions of Pamelor include monoamine oxidase inhibitors (MAOIs), cimetidine (Tagamet), alcohol, barbiturates, and benzodiazepines. This is not a complete list of drug interactions with Pamelor. Please consult your prescribing doctor for more information. Safe use of Pamelor during pregnancy and lactation has not been established; therefore, the potential benefits must be weighed against the possible hazards.
Our Pamelor Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Pamelor in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these serious side effects:
- fast, pounding, or uneven heart rate;
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
- sudden numbness or weakness, especially on one side of the body;
- sudden headache, confusion, problems with vision, speech, or balance;
- confusion, hallucinations, or seizure (convulsions);
- easy bruising or bleeding, unusual weakness;
- restless muscle movements in your eyes, tongue, jaw, or neck;
- extreme thirst with headache, nausea, vomiting, and weakness;
- feeling light-headed or fainting; or
- urinating less than usual or not at all.
Less serious side effects may include:
- nausea, vomiting, stomach pain, loss of appetite;
- constipation or diarrhea;
- weight changes;
- dry mouth, unpleasant taste;
- weakness, lack of coordination;
- numbness or tingly feeling;
- blurred vision, headache, ringing in your ears;
- mild skin rash;
- breast swelling (in men or women); or
- increased sweating.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Pamelor (Nortriptyline HCl) »
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Pamelor FDA Prescribing Information: Side Effects
Included in the following list are a few adverse reactions that have not been reported with this specific drug. However, the pharmacologic similarities among the tricyclic antidepressant drugs require that each of the reactions be considered when nortriptyline is administered.
Confusional states (especially in the elderly) with hallucinations, disorientation, delusions; anxiety, restlessness, agitation; insomnia, panic, nightmares; hypomania; exacerbation of psychosis.
Dry mouth and, rarely, associated sublingual adenitis; blurred vision, disturbance of accommodation, mydriasis; constipation, paralytic ileus; urinary retention, delayed micturition, dilation of the urinary tract.
Nausea and vomiting, anorexia, epigastric distress, diarrhea, peculiar taste, stomatitis, abdominal cramps, blacktongue.
Gynecomastia in the male, breast enlargement and galactorrhea in the female; increased or decreased libido, impotence; testicular swelling; elevation or depression of blood sugar levels; syndrome of inappropriate ADH (antidiuretic hormone) secretion.
Jaundice (simulating obstructive), altered liver function; weight gain or loss; perspiration; flushing; urinary frequency, nocturia; drowsiness, dizziness, weakness, fatigue; headache; parotid swelling; alopecia.
Though these are not indicative of addiction, abrupt cessation of treatment after prolonged therapy may produce nausea, headache, and malaise.
Read the entire FDA prescribing information for Pamelor (Nortriptyline HCl) »
Additional Pamelor Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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