Pancreatic Cancer (cont.)
Francis W. Nugent, MD
Dr. F.W. Nugent is a medical oncologist specializing in gastrointestinal cancers with a special interest in pancreatic cancer. Dr. Nugent graduated from Middlebury College with a bachelors degree in religion before graduating from Albany Medical College. He presently serves as vice-chairman of medical oncology at the Lahey Clinic in Burlington, Massachusetts.
Keith E. Stuart, MD
Dr. Keith E. Stuart is a medical oncologist specializing in the study and treatment of cancers involving the gastrointestinal tract, with a special interest in tumors involving the liver. He was educated at Harvard University (graduating magna cum laude) and Albert Einstein College of Medicine and did his medical training at the New England Deaconess Hospital.
In this Article
- Pancreatic cancer facts
- What is the pancreas, and what is the function of the pancreas?
- What is cancer?
- What is pancreatic cancer?
- What are pancreatic cancer causes and risk factors?
- What are the symptoms and signs of pancreatic cancer?
- How is the diagnosis of pancreatic cancer made?
- How is pancreatic cancer staged?
- What is the treatment for resectable pancreatic cancer?
- What is the treatment for locally advanced unresectable pancreatic cancer?
- What is the treatment for metastatic pancreatic cancer?
- What are side effects of pancreatic cancer treatment?
- What is the prognosis of pancreatic cancer?
- What research is being done on pancreatic cancer?
- Is complimentary or alternative therapy effective in pancreatic cancer treatment?
- Can pancreatic cancer be prevented?
- Where can people get support when coping with pancreatic cancer?
- Where can people find additional information about pancreatic cancer?
- Pancreatic Cancer - Slideshow
- Pictures of Pancreas - Image Collection
- Cancer-Fighting Foods - Slideshow
- Find a local Oncologist in your town
What are the symptoms and signs of pancreatic cancer?
Because the pancreas lies deep in the belly in front of the spine, pancreatic cancer often grows silently for months before it is discovered. Early symptoms can be absent or quite subtle. More easily identifiable symptoms develop once the tumor grows large enough to press on other nearby structures such as nerves (which causes pain), the intestines (which affects appetite and causes nausea along with weight loss), or the bile ducts (which causes jaundice or a yellowing of the skin and can cause loss of appetite and itching). Symptoms in women rarely differ from those in men. Once the tumor sheds cancer cells into the blood and lymph systems and metastasizes, different symptoms usually arise depending on the location of the metastasis. Frequent sites of metastasis for pancreatic cancer include the liver, the lymph nodes, and the lining of the abdomen (called the peritoneum). Unfortunately, most pancreatic cancers are found after the cancer has grown beyond the pancreas or has metastasized to other places.
How is the diagnosis of pancreatic cancer made?
Most people with pancreatic cancer first present to their primary care doctor complaining of nonspecific symptoms. These complaints trigger an evaluation often including a physical examination (usually normal), blood tests, X-rays, and an ultrasound. If pancreatic cancer is present, the likelihood of an ultrasound revealing an abnormality in the pancreas is about 75%. If a problem is identified, frequently a computed tomography (CT) scan is performed as the next step in the evaluation. A pancreatic mass and the suspicion of pancreatic cancer is then raised and a biopsy is performed to yield a diagnosis.
Different strategies can be used to perform a biopsy of the suspected cancer. Often, a needle biopsy of the liver through the belly wall (percutaneous liver biopsy) will be used if it appears that there has been spread of the cancer to the liver. If the tumor remains localized to the pancreas, biopsy of the pancreas directly usually is performed with the aid of a CT. A direct biopsy also can be made via an endoscope put down the throat and into the intestines. A camera on the tip of the endoscope allows the endoscopist to advance the endoscope within the intestine. An ultrasound device at the tip of the endoscope locates the area of the pancreas to be biopsied, and a biopsy needle is passed through a working channel in the endoscope to obtain tissue from the suspected cancer. Ultimately, a tissue diagnosis is the only way to make the diagnosis with certainty, and the team of doctors works to obtain a tissue diagnosis in the easiest way possible.
In addition to radiologic tests, suspicion of a pancreatic cancer can arise from the elevation of a "tumor marker," a blood test which can be abnormally high in people with pancreatic cancer. The tumor marker most commonly associated with pancreatic cancer is called the "CA 19-9." It is often released into the bloodstream by pancreatic cancer cells and may be elevated in patients newly found to have the disease. Unfortunately, the CA 19-9 test is not specific for pancreatic cancer. Other cancers as well as some benign conditions can cause the CA 19-9 to be elevated. Sometimes (about 10% of the time) the CA 19-9 will be at normal levels in the blood despite a confirmed diagnosis of pancreatic cancer, so the tumor marker is not perfect. It can be helpful, however, to follow during the course of illness since its rise and fall may help guide appropriate therapy.
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