July 25, 2016

Pangamic Acid

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What other names is Pangamic Acid known by?

Acide Pangamique, Ácido Pangámico, Calcium Pangamate, Calgam, Di-isopropylamine Dichloroacetate, Vitamin B15, Vitamine B15.

What is Pangamic Acid?

There is no standard chemical identity for pangamic acid. Formulations can include one or more of the following: sodium gluconate, calcium gluconate, glycine, diisopropylamine dichloroacetate, dimethylglycine, calcium chloride, dicalcium phosphate, stearic acid, cellulose, or other chemical compounds.

Pangamic acid is the name given to a product originally claimed to contain D-gluconodimethyl aminoacetic acid, which was obtained from apricot kernels and later from rice bran. It is also referred to as vitamin B15, but pangamic acid is not generally recognized as a vitamin.

Research by Russian sports scientists focused attention on pangamic acid, but little, if any, research has been conducted in the US.

Natural sources for D-gluconodimethyl aminoacetic acid include brewer's yeast, whole brown rice, sesame seeds, and pumpkin seeds.

Despite serious safety concerns, pangamic acid is used for improving exercise endurance; treating asthma and related diseases, skin conditions including eczema, lung problems, painful nerve and joint conditions, cancer, and arthritis; improving the oxygenation of the heart, brain, and other vital organs; and "detoxifying" the body. It is also used for treating alcoholism, hangovers, and fatigue; protecting against urban air pollutants; extending cell life; strengthening the immune system; lowering blood cholesterol levels; and assisting in hormone regulation.

Possibly Ineffective for...

  • Improving exercise endurance.

Insufficient Evidence to Rate Effectiveness for...

  • Asthma.
  • Eczema and other skin conditions.
  • Lung conditions.
  • Painful nerve and joint problems.
  • Alcoholism.
  • Fatigue.
  • High cholesterol.
  • Other conditions.
More evidence is needed to rate the effectiveness of pangamic acid for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


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