Panhematin (Hemin) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Panhematin

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Poorly controlled high blood pressure ultimately can cause damage to blood vessels in the eye, thickening of the heart muscle and heart attacks, hardening of the arteries (arteriosclerosis), kidney failure, and strokes.
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Panhematin

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Panhematin®
(hemin) for Injection

PANHEMATIN (hemin for injection) should only be used by physicians experienced in the management of porphyrias in hospitals where the recommended clinical and laboratory diagnostic and monitoring techniques are available.

PANHEMATIN (hemin) therapy should be considered after an appropriate period of alternate therapy (i.e., 400 g glucose/day for 1 to 2 days). (See "WARNINGS", "PRECAUTIONS" and "DOSAGE AND ADMINISTRATION" sections.)

DRUG DESCRIPTION

PANHEMATIN (hemin for injection) is an enzyme inhibitor derived from processed red blood cells. Hemin for injection was known previously as hematin. The term hematin has been used to describe the chemical reaction product of hemin and sodium carbonate solution. Hemin is an iron containing metalloporphyrin. Chemically hemin is represented as chloro [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato (2-)-N²¹,N²²,N²³,N²⁴] iron. The structural formula for hemin is:

PANHEMATIN® (HEMIN) Structural Formula Illustration

PANHEMATIN (hemin) is a sterile, lyophilized powder suitable for intravenous administration after reconstitution. Each dispensing vial of PANHEMATIN contains the equivalent of 313 mg hemin, 215 mg sodium carbonate and 300 mg of sorbitol. The pH may have been adjusted with hydrochloric acid; the product contains no preservatives. When mixed as directed with Sterile Water for Injection, USP, each 43 mL provides the equivalent of approximately 301 mg hematin (7 mg/mL).

What are the possible side effects of hemin (Panhematin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using hemin and call your doctor at once if you have a serious side effect such as:

urinating less than usual or not at all;
swelling, weight gain, feeling short of breath;
fever;
easy bruising or bleeding; or
swelling, pain, or irritation around the IV needle.

This is not a complete list of side effects...

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What are the precautions when taking hemin (Panhematin)?

Before using hemin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

Though unlikely, it is possible for this medication to contain substances that could cause infections because it is made from human plasma. Notify your doctor immediately if you develop early signs of an infection such as a persistent sore throat or fever, yellowing eyes or skin, or dark urine.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not...

Read All Potential Precautions of Panhematin »

Last reviewed on RxList: 11/7/2008
This monograph has been modified to include the generic and brand name in many instances.