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Reversible renal shutdown has occurred with administration of excessive doses (See "PRECAUTIONS" section).
Phlebitis with or without leucocytosis and with or without mild pyrexia has occurred after administration of hematin through small arm veins.
There have been post-marketing and literature reports of thrombocytopenia and coagulopathy (including prolonged prothrombin time and prolonged partial thromboplastin time) in patients receiving PANHEMATIN (hemin) . The initial literature report8 described coagulopathy occurring in a patient receiving hematin therapy. This patient exhibited prolonged prothrombin time and partial thromboplastin time, thrombocytopenia, mild hypofibrogenemia, mild elevation of fibrin split products, and a 10% fall in hematocrit.
No information provided.
REFERENCES
8. Morris, D.L., et al., Coagulopathy Associated with Hematin Treatment for Acute Intermittent Prophyria, Ann Intern Med 95:700-701, 1981.
Last reviewed on RxList: 11/7/2008
This monograph has been modified to include the generic and brand name in many instances.
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