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Panretin® (alitretinoin) gel is indicated for topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. Panretin® (alitretinoin) gel is not indicated when systemic anti-KS therapy is required (e.g., more than 10 new KS lesions in the prior month, symptomatic lymphedema, symptomatic pulmonary KS, or symptomatic visceral involvement). There is no experience to date using Panretin® (alitretinoin) gel with systemic anti-KS treatment.
DOSAGE AND ADMINISTRATION
Panretin® (alitretinoin) gel should initially be applied two (2) times a day to cutaneous KS lesions. The application frequency can be gradually increased to three (3) or four (4) times a day according to individual lesion tolerance. If application site toxicity occurs, the application frequency can be reduced. Should severe irritation occur, application of drug can be temporarily discontinued for a few days until the symptoms subside.
Sufficient gel should be applied to cover the lesion with a generous coating. The gel should be allowed to dry for three to five minutes before covering with clothing. Because unaffected skin may become irritated, application of the gel to normal skin surrounding the lesions should be avoided. In addition, do not apply the gel on or near mucosal surfaces of the body.
A response of KS lesions may be seen as soon as two weeks after initiation of therapy but most patients require longer application. With continued application, further benefit may be attained. Some patients have required over 14 weeks to respond. In clinical trials, Panretin® (alitretinoin) gel was applied for up to 96 weeks. Panretin® (alitretinoin) gel should be continued as long as the patient is deriving benefit.
Occlusive dressings should not be used with Panretin® (alitretinoin) gel.
Panretin® (alitretinoin) gel is available in tubes containing 60 grams. Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature].
Manufactured for: Ligand Pharmaceuticals Incorporated, San Diego, CA 92121. By: Stiefel Laboratories, Inc., Coral Gables, FL 33134. (Rev. 0598). FDA revision date: 11/21/2000
Last reviewed on RxList: 11/17/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Panretin Information
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