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Papaverine Injection

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Papaverine Injection

PAPAVERINE HYDROCHLORIDE INJECTION, USP (papaverine hydrochloride injection)

This product is to be used by or under the direction of a physician.

Each vial contains a sufficient amount to permit withdrawal and administration of the volume specified on the label.

DRUG DESCRIPTION

Papaverine hydrochloride is the hydrochloride of an alkaloid obtained from opium or prepared synthetically. It belongs to the benzylisoquinoline group of alkaloids. It does not contain a phenanthrene group as do morphine and codeine.

Papaverine hydrochloride is 6,7-dimethoxy-1-veratrylisoquinoline hydrochloride and contains, on the dried basis, not less than 98.5% of C20H21NO4•HCI. The molecular weight is 375.85. The structural formula is as shown:

Papaverine hydrochloride Structural Formula Illustration

Papaverine hydrochloride occurs as white crystals or white crystalline powder. One gram dissolves in about 30 mL of water and in 120 mL of alcohol. It is soluble in chloroform and practically insoluble in ether.

Papaverine Hydrochloride Injection is a clear, colorless to pale-yellow solution.

Papaverine hydrochloride, for parenteral administration, is a smooth-muscle relaxant that is available in vials containing 30 mg/mL papaverine hydrochloride. Each vial also contains edetate disodium, 0.005%. Sodium hydroxide may have been added during manufacture to adjust the pH.

What are the possible side effects of papaverine injection ()?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor at once if you have a serious side effect such as:

  • low fever, nausea, stomach pain, loss of appetite;
  • dark urine, clay-colored stools;
  • jaundice (yellowing of the skin or eyes);
  • warmth, redness, or tingly feeling in your face;
  • swelling, pain, or irritation around the IV needle;
  • fast heart rate; or
  • skin rash, bruising, severe tingling, numbness,...

Read All Potential Side Effects and See Pictures of Papaverine Injection »

Last reviewed on RxList: 2/25/2009
This monograph has been modified to include the generic and brand name in many instances.

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