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Papaverine Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 2/23/2016

Papaverine Hydrochloride Sustained Release Capsules is a vasodilator drug that relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily and is used for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. Side effects of Papaverine include nausea, stomach discomfort, loss of appetite, dizziness, drowsiness, tiredness, headache, skin rash, decreased appetite, diarrhea, constipation, increased sweating, facial flushing (warmth, redness, or tingly feeling), general discomfort or feeling of being unwell (malaise), and irregular heartbeats.

The dose of Papaverine Sustained Release Capsules is one 150 mg capsule taken orally every 12 hours. Papaverine may interact with levodopa (Dopar, Larodopa). Tell your doctor all medications and supplements you use. It is not known whether Papaverine will harm an unborn baby. Do not take Papaverine without first talking to your doctor if you are pregnant. It is also not known whether Papaverine passes into breast milk.

Our Papaverine Hydrochloride Sustained Release Capsules Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Papaverine in Detail - Patient Information: Side Effects

Stop taking papaverine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Stop taking papaverine and contact your doctor if your skin or eyes develop a yellow tint.

Other, less serious side effects may be more likely to occur. Continue to take papaverine and talk to your doctor if you experience

  • nausea, decreased appetite, diarrhea, or constipation;
  • dizziness or drowsiness;
  • headache;
  • sweating and flushing;
  • a rash; or
  • irregular heartbeats.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Papaverine (Papaverine)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Papaverine FDA Prescribing Information: Side Effects
(Adverse Reactions)


Although occurring rarely, the reported side effects of papaverine include nausea, abdominal distress, anorexia, constipation, malaise, drowsiness, vertigo, sweating, headache, diarrhea, skin rash, flushing of face, increase in heart rate and depth of respiration and slight increase in blood pressure.

Read the entire FDA prescribing information for Papaverine (Papaverine)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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