November 27, 2015
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"The cystic fibrosis (CF) drug Orkambi (Vertex Pharmaceuticals) has received a green light from the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP).

Orkambi is a fixed-dose oral combination "...




Ocular overdosage will cause dilation of the pupils. Systemic overdosage or ingestion of large doses may result in hypertension, cardiac arrhythmias, sub-sternal discomfort, headache, sweating, nausea, vomiting, and gastrointestinal irritation. Patients with systemic overdosage should be carefully monitored and treated symptomatically.


PAREMYD® (hydroxyamphetamine hydrobromide, tropicamide) Solution (hydroxyamphetamine hydrobromide/tropicamide ophthalmic solution)1%/0.25% should not be used in patients with angle-closure glaucoma or in those with narrow angles in whom dilation of the pupil may precipitate an attack of angle-closure glaucoma. This product is also contraindicated in patients who are hypersensitive to any of its components.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 2/20/2009


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