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Parnate

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Parnate

Parnate

Parnate Side Effects Center

Medical Editor: Charles Patrick Davis, MD, PhD

Parnate (tranylcypromine sulfate) Tablets is part of a drug class of monoamine oxidase inhibitors (MAOI) and is available in generic form. It is used the treatment of major depressive episode without melancholia. Parnate should be used in adults who are closely supervised. Some side effects may include but are not limited to: frequent headaches, vision problems, or sensitivity to light.

Parnate dosage (available in 10 mg tablets) should be adjusted to the requirements of the individual patient. If there are no signs of improvement after about 2 weeks, then the dosage may be increased (10 mg per day) at intervals of 1 to 3 weeks and extended to a maximum of 60 mg per day. A serious side effect of Parnate is the occurrence of hypertensive crises which can be fatal. Inform the doctor about all the other prescription and over-the-counter medications used, including vitamins, minerals, and herbal products; Parnate interacts with many other medications. Parnate use in pregnancy and lactating women should consider risks versus benefits; use in pediatric patients is not indicated.

Our Parnate (tranylcypromine sulfate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Parnate in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Stop using tranylcypromine and call your doctor at once if you have any of these serious side effects:

  • frequent headaches, vision problems, sensitivity to light;
  • fast or pounding heart beats, tight feeling in your chest or throat;
  • swelling of your ankles or feet;
  • pale skin, easy bruising or bleeding, unusual weakness;
  • nausea, vomiting, dizziness, sweating, stiffness in your neck;
  • confusion, lack of coordination, feeling light-headed, fainting; or
  • tremors, muscle twitches you cannot control.

Less serious side effects may include:

  • feeling restless, weak, or drowsy;
  • nausea, diarrhea or constipation, loss of appetite, stomach pain;
  • chills, numbness or tingly feeling;
  • dry mouth, decreased urination;
  • blurred vision, ringing in your ears; or
  • impotence, difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Parnate (Tranylcypromine) »

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Parnate Overview - Patient Information: Side Effects

SIDE EFFECTS: See also Warning section.

Dizziness, drowsiness, tiredness, weakness, problems sleeping, constipation, and dry mouth may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: fainting, mental/mood changes (e.g., agitation, confusion), muscle stiffness/twitching, changes in sexual ability/interest, shaking (tremor), shivering, swollen ankles/legs, unusual weight gain, vision changes (e.g., double/blurred vision).

Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: severe stomach/abdominal pain, persistent nausea/vomiting, seizures, dark urine, yellowing eyes/skin.

This drug may rarely cause an attack of extremely high blood pressure (hypertensive crisis), which may be fatal. Many drug and food interactions can increase this risk (See also Drug Interaction section.) Stop taking tranylcypromine and seek immediate medical attention if any of these serious side effects occur: frequent/severe headache, fast/slow/irregular/pounding heartbeat, chest pain, neck stiffness/soreness, severe nausea/vomiting, sweating/clammy skin (sometimes with fever), widened pupils, sudden sensitivity to light (photophobia).

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Parnate (Tranylcypromine)»

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Parnate FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Overstimulation which may include increased anxiety, agitation, and manic symptoms is usually evidence of excessive therapeutic action. Dosage should be reduced, or a phenothiazine tranquilizer should be administered concomitantly.

Patients may experience restlessness or insomnia; may notice some weakness, drowsiness, episodes of dizziness or dry mouth; or may report nausea, diarrhea, abdominal pain, or constipation. Most of these effects can be relieved by lowering the dosage or by giving suitable concomitant medication.

Tachycardia, significant anorexia, edema, palpitation, blurred vision, chills, and impotence have each been reported.

Headaches without blood pressure elevation have occurred.

Rare instances of hepatitis, skin rash, and alopecia have been reported.

Impaired water excretion compatible with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) has been reported.

Tinnitus, muscle spasm, tremors, myoclonic jerks, numbness, paresthesia, urinary retention, and retarded ejaculation have been reported.

Hematologic disorders including anemia, leukopenia, agranulocytosis, and thrombocytopenia have been reported.

Post-Introduction Reports: The following are spontaneously reported adverse events temporally associated with use of PARNATE (tranylcypromine) . No clear relationship between PARNATE (tranylcypromine) and these events has been established. Localized scleroderma, flare-up of cystic acne, ataxia, confusion, disorientation, memory loss, urinary frequency, urinary incontinence, urticaria, fissuring in corner of mouth, akinesia.

Read the entire FDA prescribing information for Parnate (Tranylcypromine) »

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Parnate - User Reviews

Parnate User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Parnate sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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