Pataday
Global Warming May Double Pollen by 2040 »
"Nov. 9, 2012 -- If you're allergic to pollen, brace yourself.
"By the year 2040, we will get about 1.5 to two times the amount of pollen that we have now," says Leonard Bielory, MD. Bielory is professor of environmental prediction at "...
Pataday
CLINICAL PHARMACOLOGY
Mechanism of Action
Olopatadine is a mast cellstabilizer and a histamine H1 antagonist. Decreased chemotaxis and inhibition of eosinophil activation has also been demonstrated.
Pharmacokinetics
Systemic bioavailability data upon topical ocular administration of PATADAY™ (olopatadine hydrochloride ophthalmic solution) solution are not available. Following topical ocular administration of olopatadine 0.15% ophthalmic solution in man, olopatadine was shown to have a low systemic exposure. Two studies in normal volunteers (totaling 24 subjects) dosed bilaterally with olopatadine 0.15% ophthalmic solution once every 12 hours for 2 weeks demonstrated plasma concentrations to be generally below the quantitation limit of the assay ( < 0.5 ng/mL). Samples in which olopatadine was quantifiable were typically found within 2 hours of dosing and ranged from 0.5 to 1.3 ng/mL. The elimination half-life in plasma following oral dosing was 8 to 12 hours, and elimination was predominantly through renal excretion. Approximately 60 - 70% of the dose was recovered in the urine as parent drug. Two metabolites, the mono-desmethyl and the N-oxide, were detected at low concentrations in the urine.
Clinical Studies
Results from clinical studies of up to 12 weeks duration demonstrate that PATADAY™ (olopatadine hydrochloride ophthalmic solution) solution when dosed once a day is effective in the treatment of ocular itching associated with allergic conjunctivitis.
Last reviewed on RxList: 1/27/2011
This monograph has been modified to include the generic and brand name in many instances.
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