Patanase Nasal Spray (Olopatadine Hydrochloride Nasal Spray) Drug Information: Overdosage and Contraindications

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May 27, 2012

Patanase Nasal Spray

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Allergy medications overview

The arsenal of allergy drugs includes dozens of medications that relieve allergy symptoms when confronted with a trigger known as an allergen. That trigger could be something from a plant, such as pollen, or something from an animal (pet dander, dust mites, cockroaches). Other allergy triggers include certain fragrances or chemical substances.

What causes a person's allergic reaction is highly individual. But the reactions are often universal: swelling and inflammation, especially around the eyes, nose, and throat, usually accompanied by itching.

Some allergy medications work against the effects of histamines, which are released during an allergic reaction. Other medications reduce swelling, affect the immune system, or affect release of other substances associated with allergic reactions.

Many allergy drugs are available without a prescription.

For what conditions are allergy medicatio...

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OVERDOSE

There have been no reported overdosages with PATANASE Nasal Spray.

Acute overdosage with this dosage form is unlikely due to the configuration of the primary container closure system. However, symptoms of antihistamine overdose may include drowsiness in adults and, initially, agitation and restlessness, followed by drowsiness in children. There is no known specific antidote to PATANASE Nasal Spray. Should overdose occur, symptomatic or supportive treatment is recommended, taking into account any concomitantly ingested medications.

No mortality was observed in rats at an intranasal dose of 3.6 mg/kg (approximately 6 times the MRHD for adults and adolescents ≥ 12 years of age and 7 times the MRHD for children 6-11 years of age on a mg/m² basis), or in dogs at an oral dose of 5 g/kg (approximately 28,000 times the MRHD for adults and adolescents ≥ 12 years of age and 33,000 the MRHD for children 6-11 years of age on a mg/m² basis). The oral median lethal dose (MLD) in mice and rats were 1,490 mg/kg and 3,870 mg/kg respectively (approximately 1,200 times and 6,500 times the MRHD for adults and adolescents ≥ 12 years of age and 1,500 times and 7,700 times the MRHD for children 6-11 years of age, on a mg/m² basis, respectively).

For additional information about overdose treatment, call a poison control center (1-800-222-1222).