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PCE ® Tablets
(erythromycin particles) in Tablets
To reduce the development of drug-resistant bacteria and maintain the effectiveness of PCE tablets and other antibacterial drugs, PCE tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
PCE tablets (erythromycin particles in tablets) are an antibacterial product containing specially coated erythromycin base particles for oral administration. The coating protects the antibiotic from the inactivating effects of gastric acidity and permits efficient absorption of the antibiotic in the small intestine. PCE tablets are available in two strengths containing either 333 mg or 500 mg of erythromycin base. PCE tablets 500 mg tablets contain no synthetic dyes or artificial colors.
Erythromycin is produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the macrolide group of antibiotics. It is basic and readily forms salts with acids. Erythromycin is a white to off-white powder, slightly soluble in water, and soluble in alcohol, chloroform, and ether. Erythromycin is known chemically as (3R*, 4S*, 5S*, 6R*, 7R*, 9R*, 11R*, 12R*, 13S*, 14R*)-4-[(2,6-dideoxy-3-C-methyl-3-O-methyl-αL-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione. The molecular formula is C37H67NO13, and the molecular weight is 733.94. The structural formula is:
PCE 333 mg Tablets
Cellulosic polymers, citrate ester, colloidal silicon dioxide, D&C Red No. 30, hydrogenated vegetable oil wax, lactose, magnesium stearate, microcrystalline cellulose, povidone, propylene glycol, sodium starch glycolate, stearic acid and vanillin.
PCE 500 mg Tablets
Cellulosic polymers, citrate ester, colloidal silicon dioxide, crospovidone, hydrogenated vegetable oil wax, microcrystalline cellulose, polyethylene glycol, povidone, propylene glycol, stearic acid, talc, titanium dioxide and vanillin. PCE 500 mg tablets contain no synthetic dyes or artificial colors.
What are the possible side effects of erythromycin?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- severe dizziness, fainting, fast or pounding heartbeats;
- nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
- diarrhea that is watery or bloody;
- hearing problems;
- vomiting or fussiness after eating (in a child taking erythromycin);...
What are the precautions when taking erythromycin pce (PCE)?
Before taking erythromycin, tell your doctor or pharmacist if you are allergic to it; or to other macrolide antibiotics (e.g., azithromycin, clarithromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, a certain type of muscle disease (myasthenia gravis).
Erythromycin may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that require immediate medical...
Last reviewed on RxList: 2/24/2012
This monograph has been modified to include the generic and brand name in many instances.
Additional PCE Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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