PCE (Erythromycin PCE) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

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Strep Throat »

What is strep throat?

While many people use the terms sore throat, tonsillitis, and strep throat interchangeably, there are significant clinical differences between these conditions. Understanding the differences can give patients a better idea of how and when to be concerned and when to seek advice from a physician.

Strep throat is only one of many possible causes of throat infection and sore throat. While strep throat is most common in children and adolescents, it can affect people of all ages.

What causes sore throat?

Sore throat has many causes. The most common causes of sore throat are infections of the throat and the surrounding structures. Any inflammation or infection of the pharynx, tonsils, esophagus (the food pipe), or larynx (the top opening part of the windpipe) may cause sore throat.

What are the tonsils and tonsillitis?

The tonsils are red, oval clumps of tissue locat...

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PCE ® Tablets
(erythromycin particles) in Tablets

To reduce the development of drug-resistant bacteria and maintain the effectiveness of PCE tablets and other antibacterial drugs, PCE tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

DRUG DESCRIPTION

PCE tablets (erythromycin particles in tablets) are an antibacterial product containing specially coated erythromycin base particles for oral administration. The coating protects the antibiotic from the inactivating effects of gastric acidity and permits efficient absorption of the antibiotic in the small intestine. PCE tablets are available in two strengths containing either 333 mg or 500 mg of erythromycin base. PCE tablets 500 mg tablets contain no synthetic dyes or artificial colors.

Erythromycin is produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the macrolide group of antibiotics. It is basic and readily forms salts with acids. Erythromycin is a white to off-white powder, slightly soluble in water, and soluble in alcohol, chloroform, and ether. Erythromycin is known chemically as (3R*, 4S*, 5S*, 6R*, 7R*, 9R*, 11R*, 12R*, 13S*, 14R*)-4-[(2,6-dideoxy-3-C-methyl-3-O-methyl-αL-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione. The molecular formula is C₃₇H₆₇NO₁₃, and the molecular weight is 733.94. The structural formula is:

PCE ® (erythromycin) Structural Formula Illustration

Inactive Ingredients

PCE 333 mg Tablets

Cellulosic polymers, citrate ester, colloidal silicon dioxide, D&C Red No. 30, hydrogenated vegetable oil wax, lactose, magnesium stearate, microcrystalline cellulose, povidone, propylene glycol, sodium starch glycolate, stearic acid and vanillin.

PCE 500 mg Tablets

Cellulosic polymers, citrate ester, colloidal silicon dioxide, crospovidone, hydrogenated vegetable oil wax, microcrystalline cellulose, polyethylene glycol, povidone, propylene glycol, stearic acid, talc, titanium dioxide and vanillin. PCE 500 mg tablets contain no synthetic dyes or artificial colors.

Last reviewed on RxList: 2/24/2012
This monograph has been modified to include the generic and brand name in many instances.