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(Generic versions may still be available.)
(erythromycin ethylsuccinate and sulfisoxazole acetyl)
Pediazole (erythromycin and sulfisoxazole) is a combination of erythromycin ethylsuccinate, USP, and sulfisoxazole acetyl, USP. When reconstituted with water as directed on the label, the granules form a white, strawberry-banana flavor suspension that provides the equivalent of 200 mg erythromycin activity and the equivalent of 600 mg of sulfisoxazole activity per teaspoonful (5 mL).
Erythromycin is produced by a strain of Saccaropolyspora erythraea and belongs to the macrolide group of antibiotics. It is basic and readily forms salts and esters. Erythromycin ethylsuccinate is the 2'-ethylsuccinyl ester of erythromycin. It is essentially a tasteless form of the antibiotic suitable for oral administration, particularly in suspension dosage forms. The chemical name is erythromycin 2'-(ethyl succinate).
Sulfisoxazole acetyl or N 1 -acetyl sulfisoxazole is an ester of sulfisoxazole. Chemically, sulfisoxazole is N-(3,4-Dimethyl-5-isoxazolyl)-N-sulfanilylacetamide.
What are the possible side effects of erythromycin and sulfisoxazole (Pediazole)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- dizziness, fainting, fast or pounding heartbeat;
- diarrhea that is watery or bloody;
- confusion, hallucinations;
- muscle pain, tenderness, or weakness with fever or flu symptoms and dark colored urine;
- white patches or sores inside your mouth or on your lips;
- fever, sore throat, and...
What are the precautions when taking erythromycin and sulfisoxazole (Pediazole)?
Before taking erythromycin with sulfisoxazole, tell the doctor or pharmacist if your child is allergic to it; or to other macrolide antibiotics (such as azithromycin, clarithromycin) or sulfa medications; or if your child has any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your child's pharmacist for more details.
Before using this medication, tell the doctor or pharmacist your child's medical history, especially of: severe allergies, asthma, blood disorders (such as porphyria, bone marrow suppression/low blood cell counts), a certain genetic condition (glucose-6-phosphate dehydrogenase/G6PD deficiency), kidney disease, liver disease, a certain type of muscle disease (myasthenia...
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
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