Pediazole (Erythromycin and Sulfisoxazole) Drug Information: Overdosage and Contraindications

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May 27, 2012

Pediazole

Ear Infection (Otitis Media) »

Ear infection or inflammation (otitis media) facts

Otitis media (ear infection or inflammation) is the most common diagnosis in sick children in the U.S.
Otitis media features fever, ear pain, and a feeling of fullness in the ear; as well as fussiness and feeding problems in young children.
Otitis media is usually an infection and/or inflammation of the middle ear.
Ear infection or inflammation causes fluid buildup in the middle ear.
A cold or other respiratory infection can lead to ear infections or inflammation.
Exposure to other children's colds as often occurs in daycare centers, raises the risk of contracting otitis media (ear infection or inflammation).
Bottlefeeding increases the risk of ear infection or inflammation in babies.
Middle ear pus causes pain and temporary hearing loss.
Rupture of the eardrum allows the pus to drain into the ear canal.
Otitis ...

Read the Ear Infection (Otitis Media) article »

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

OVERDOSE

No information is available on a specific result of overdose with Pediazole (erythromycin and sulfisoxazole) . Overdosage of erythromycin should be handled with the prompt elimination of unabsorbed drug and all other appropriate measures. Erythromycin is not removed by peritoneal dialysis or hemodialysis.

The amount of a single dose of sulfisoxazole that is either associated with symptoms of overdosage or is likely to be life-threatening has not been reported. Signs and symptoms of overdosage reported with sulfonamides include anorexia, colic, nausea, vomiting, dizziness, headache, drowsiness and unconsciousness. Pyrexia, hematuria and crystalluria may be noted. Blood dyscrasias and jaundice are potential late manifestations of overdosage.

General principles of treatment include the immediate discontinuation of the drug, instituting gastric lavage or emesis, forcing oral fluids, and administering intravenous fluids if urine output is low and renal function is normal. The patient should be monitored with blood counts and appropriate blood chemistries, including electrolytes. If the patient becomes cyanotic, the possibility of methemoglobinemia should be considered and, if present, the condition should be treated appropriately with intravenous 1% methylene blue. If a significant blood dyscrasia or jaundice occurs, specific therapy should be instituted for these complications. Peritoneal dialysis is not effective, and hemodialysis is only moderately effective in removing sulfonamides.

The acute toxicity of sulfisoxazole in animals is as follows:


Species	LD ₅₀± S.E. Â· (mg/kg)
mouse	5700 ± 235
rats	>10,000
rabbits	>2000

CONTRAINDICATIONS

Pediazole (erythromycin and sulfisoxazole) is contraindicated in the following patient populations:

Patients with a known hypersensitivity to either of its components, children younger than 2 months, pregnant women at term, and mothers nursing infants less than 2 months of age.

Use in pregnant women at term, in children less than 2 months of age, and in mothers nursing infants less than 2 months of age is contraindicated because sulfonamides may promote kernicterus in the newborn by displacing bilirubin from plasma proteins.

Erythromycin is contraindicated in patients taking terfenadine. ( See PRECAUTIONS -- Drug Interactions. )

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.