May 1, 2017
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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Pediazole Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking erythromycin and sulfisoxazole (Pediazole)?

Do not take this medication if you are allergic to erythromycin or sulfisoxazole, or if::

  • you are in your 9th month of pregnancy; or
  • you are breast-feeding a baby younger than 2 months old.

Erythromycin may interact with these medicines and could cause dangerous or life-threatening heart rhythm disorders.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

  • kidney disease;
  • liver disease;
  • diabetes;
  • myasthenia gravis;
  • a history of "Long QT Syndrome"; or
  • if you are allergic to sulfa drugs or other antibiotics such as azithromycin (Zithromax) or clarithromycin (Biaxin).

FDA pregnancy category C. It is not known whether erythromycin and sulfisoxazole is harmful to an unborn baby when taken in early pregnancy. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Do not take erythromycin and sulfisoxazole during late pregnancy.

Erythromycin and sulfisoxazole can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not take erythromycin and sulfisoxazole if you are breast-feeding a baby younger than 2 months old.

Older adults may be more likely to have side effects from this medication.

Do not give this medication to a child younger than 2 months old.

How should I take erythromycin and sulfisoxazole (Pediazole)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Take erythromycin and sulfisoxazole with a full glass (8 ounces) of water. Drink plenty of fluids every day while taking this medication.

Take this medication with food or milk if it upsets your stomach.

Shake the liquid medicine well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Erythromycin and sulfisoxazole is usually given 3 or 4 times daily. Try to take the medicine at evenly spaced intervals throughout the day.

Take this medication for the full prescribed length of time. Your symptoms may get better before the infection is completely cleared. Erythromycin and sulfisoxazole will not treat a viral infection such as the common cold or flu.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using erythromycin and sulfisoxazole. You may need to stop using the medicine for a short time.

Erythromycin and sulfisoxazole can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using erythromycin.

Store this medication in the refrigerator. Do not freeze. Throw away any unused medicine that is older than 14 days

Side Effects Centers

Pediazole - User Reviews

Pediazole User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Pediazole sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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