Pediotic (Neomycin, Polymyxin B and Hydrocortisone) Drug Information: Side Effects and Drug Interactions

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May 27, 2012

Pediotic

Swimmer's Ear »

Swimmer's ear facts

Swimmer's ear, or external otitis, is typically a bacterial infection of the outer ear canal skin and can occur in acute and chronic forms.
Excessive water exposure and frequent instrumentation (usually cotton swabs) of the ear canal are important causative factors.
Itchy ears, a feeling of fullness, swelling, drainage, and pain are early symptoms.
Antibiotic ear drops and avoidance of water are frequently necessary for treatment.
Proper ear care can avoid most infections.

What is "swimmer's ear" or acute external otitis?

External otitis or "swimmer's ear" is an infection of the skin covering the outer ear and ear canal. Acute external otitis is commonly a bacterial infection caused by streptococcus, staphylococcus, or pseudomonas types of bacteria. The swimmer's ear infection is usually caused by excessive water exposure from sw...

Read the Swimmer's Ear article »

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Pediotic

Anatomy of an Ear Infection Slideshow Pictures

Medical Illustration of the Ear Image Collection

Tinnitus (Ringing of the Ears) Slideshow Pictures

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SIDE EFFECTS

Neomycin occasionally causes skin sensitization. Ototoxicity and nephrotoxicity have also been reported (see WARNINGS). Adverse reactions have occurred with topical use of antibiotic combinations including neomycin and polymyxin B. Exact incidence figures are not available since no denominator of treated patients is available. The reaction occurring most often is allergic sensitization. In one clinical study, using a 20% neomycin patch, neomycin-induced allergic skin reactions occurred in two of 2,175 (0.09%) individuals in the general population.² In another study, the incidence was found to be approximately 1%.³

The following local adverse reactions have been reported with topical corticosteroids, especially under occlusive dressings: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria. Stinging and burning have been reported rarely when this drug has gained access to the middle ear.

DRUG INTERACTIONS

No information provided.

REFERENCES

2. Leyden JJ, Kligman AM. Contact dermatitis to neomycin sulfate. JAMA. 1979;242:1276-1278.

3. Prystowsky SD, Allen AM, Smith RW, Nonomura JH, Odom RB, Akers WA. Allergic contact hypersensitivity to nickel, neomycin, ethylenediamine, and benzocaine: relationships between age, sex, history of exposure, and reactivity to standard patch tests and use tests in a general population. Arch Dermatol. 1979;115:959-962.

Last reviewed on RxList: 2/23/2009
This monograph has been modified to include the generic and brand name in many instances.