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A severe allergic reaction (e.g., anaphylaxis) after a previous dose of Pentacel (tetanus toxoid conjugate) vaccine, any ingredient of this vaccine, or any other tetanus toxoid, diphtheria toxoid, pertussis-containing vaccine, inactivated poliovirus vaccine or H influenzae type b vaccine is a contraindication to administration of Pentacel vaccine. (See DESCRIPTION). Because of uncertainty as to which ingredient of the vaccine may be responsible, none of the ingredients should be administered. Alternatively, such individuals may be referred to an allergist for evaluation if further immunizations are considered.

The following events are contraindications to administration of any pertussis-containing vaccine, (19) including Pentacel (tetanus toxoid conjugate) vaccine.

• Encephalopathy (e.g., coma, decreased level of consciousness, prolonged seizures) within 7 days of a previous dose of a pertussis containing vaccine that is not attributable to another identifiable cause.
• Progressive neurologic disorder, including infantile spasms, uncontrolled epilepsy, progressive encephalopathy. Pertussis vaccine should not be administered to individuals with such conditions until the neurologic status is clarified and stabilized.

Last reviewed on RxList: 7/25/2008
This monograph has been modified to include the generic and brand name in many instances.